gms | German Medical Science

10. Deutscher Kongress für Versorgungsforschung, 18. GAA-Jahrestagung

Deutsches Netzwerk Versorgungsforschung e. V.
Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e. V.

20.-22.10.2011, Köln

Long term impact of second generation antipsychotics, physical activity, and waist size on objective and subjective physical health in patients with schizophrenia (ELAN-Study)

Meeting Abstract

  • author presenting/speaker Gerhard Wilhelm Eschweiler - Universitätsklinik für Psychiatrie und Psychotherapie Tübingen, Tübingen, Germany
  • author Wiltrud Bayer - Bezirksklinikum Regensburg, Regensburg, Germany
  • author Susanne Jaeger - Universität Ulm, Abteilkung Psychiatrie und Psychotherapie I, Ravensburg, Germany
  • author Carmen Pfiffner - Universität Ulm, Abteilkung Psychiatrie und Psychotherapie I, Ravensburg, Germany
  • author Thomas Messer - Danuvius Klinik, Pfaffenhofen, Germany
  • author Karel Frasch - Universität Ulm, Abteilung Psychiatrie und Psychotherapie II, Günzburg, Germany
  • author Prisca Weiser - Universität Ulm, Abteilung Psychiatrie und Psychotherapie II, Günzburg, Germany
  • author Thomas Becker - Universität Ulm, Abteilung Psychiatrie und Psychotherapie II, Günzburg, Germany
  • author Tilman Steinert - Universität Ulm, Abteilung Psychiatrie und Psychotherapie I, Ravensburg, Germany
  • author Reinhold Kilian - Universität Ulm, Abteilung Psychiatrie und Psychotherapie II, Günzburg, Germany
  • corresponding author Gerhard Längle - Universtität Tübingen, Zwiefalten, Germany

10. Deutscher Kongress für Versorgungsforschung. 18. GAA-Jahrestagung. Köln, 20.-22.10.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11dkvf149

DOI: 10.3205/11dkvf149, URN: urn:nbn:de:0183-11dkvf1498

Published: October 12, 2011

© 2011 Eschweiler et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Background: Background: Increased body weight, visceral adiposity and lack of physical activity/fitness are common in psychotic disorders and may be related to or even predict physical well being. The relationships between different antipsychotic treatments and physical-well being, prevalence of hypertonia and hyperlipidemia, metabolic and anthropometric changes, and physical activity/ fitness of patients with psychotic disorders was evaluated under real-world treatment conditions over 24 months.

Materials and methods: 374 patients with schizophrenia or schizoaffective disorders were followed at 0, 6, 12, 18 and 24 months after discharge from inpatient treatment. A cut-off for the waist circumference at risk for the Framginham coronary heart disease risk index (CHDRI, Ardern et al., Obesity 2004) was adapted for BMI and sex.

Results: Results: At discharge, 31% of patients were obese (BMI > 30 kg/m²), 59% out of 363 patients had a waist at risk for CHDRI and 27.5 % had arterial hypertension, 13.2% of those patients with normal waist and 37% of patients beyond the risk waist. 3.9% of the patients had insulin dependent diabetes mellitus. Physical fitness after 6 months (ability to climb 3 stairs without sweating) was a protective factor for subjective general and physical well-being at that time point: OR 2.5 (CI 1.6–3.9, n=316). The choice of second generation antipsychotics (quetiapine, risperidone or olanzapine) had no impact on physical well-being, as statements about physical exercise, BMI, waist circumference, age or sex had also no significant impact on physical well-being at the same point in time or at the end of study. Physical fitness at 6 months, however, predicted subjective physical well being at 24 months (n=272, OR 1.7 CI 1.1–2.8).

Conclusions: In this study, subjective well-being from physical health and objective metabolic health was mainly related to physical fitness and lack of visceral adiposity, but was unaffected by different second generation antipsychotic treatments. Attractive exercise programs and daily physical activities should be offered to psychotic patients.

Acknowledgement: The ELAN study was funded as an investigator-initiated research project by a grant fromAstraZeneca Deutschland to the University of Tübingen.