Article
Alcohol intake and the risk of osteonecrosis of the femoral head: a dose-response meta-analysis of case-control studies
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Authors
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Byung-Ho Yoon
- Inje University College of Medicine, Seoul, Korea , Seoul, Korea, Republic of (South Korea)
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Woo-Lam Jo
- The Catholic University of Seoul, Korea., Seoul, Korea, Republic of (South Korea)
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Jun-Il Yoo
- Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South Korea)
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Young-Kyun Lee
- Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South Korea)
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Yong-Chan Ha
- Chung-Ang University College of Medicine, Seoul, Korea, Republic of (South Korea)
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Kyung-Hoi Koo
- Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South Korea)
| Published: | October 23, 2017 |
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Outline
Text
Objectives: Studies examining the association between alcohol intake and the risk of osteonecrosis of the femoral head (ONFH) have inconsistent results. The purpose of this study was to examine and summarize the evidence regarding the association between alcohol intake and ONFH based on results from case-control studies.
Methods: This analysis included five case-control studies reporting data from 1,251 individuals. With respect to alcohol intake habits (never, former, or current), average drinking consumption (g/week) and cumulative drinking consumption (drink-years) were extracted. The risk of ONFH was evaluated, and a two-stage dose-response meta-analysis was performed using restricted cubic splines with four knots at fixed percentiles of 5%, 35%, 65%, and 95% of the distribution.
Results and Conclusion: Former alcohol intake increased the risk of ONFH with marginal significance (odds ratio [OR], 2.62; p = 0.055). Current alcohol intake was associated with an increased risk of ONFH on occasional (OR, 3.63; p < 0.001) and regular drinking (OR, 5.90; p < 0.001). The dose-response meta-analysis revealed that the risk of ONFH increased by 35.3% for every 100 g/week (95% confidence interval [CI], 1.24-1.47; p < 0.001) and by 44.1% for every 500 g drink-years (95% CI, 1.295-1.601; p < 0.001).
No image found for uniqueTag: Dosereponserelations
Current and cumulative alcohol intakes were positively associated with an increased risk of ONFH in a non-linear pattern. However, further studies to elucidate the threshold of alcohol consumption to prevent ONFH in the general population are required.
