gms | German Medical Science

27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

Influence of physiotherapy on tumour oxygenation using intensified respiration by means of respiratory endurance training (SpiroTiger®)

Meeting Abstract

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  • corresponding author presenting/speaker Kay-Uwe Hanusch - Physiotherapie Aeskulap-Klinik Brunnen, Schweiz
  • Bernd Süsse - Onkologie Aeskulap-Klinik Brunnen
  • Hans Ogal - Schmerzambulanz Aeskulap-Klinik Brunnen

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPE635

The electronic version of this article is the complete one and can be found online at:

Published: March 20, 2006

© 2006 Hanusch et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Introduction: There are increasing references in literature about the possibility that reduced oxygenation VO2 of the tumour can contribute to the resistance of cytostatic treatment or radiation therapy and encourage angiogenesis. It is attempted to counteract this resistance using different clinical methods, among others cardiovascular modifications by means of temperature increases (hyperthermia) and the erythropoietic possibility using erythropoietin supplementation. The influence of intensified respiration, which up until now has only be given low consideration, presents an activity for physiotherapy (graphic). This makes it conceivable that oxygen saturation (SaO2/SvO2) can be improved through intensified respiration with a sub-maximal use of the FVC and a subsequent left shift of the oxygen dissociation curve into the lung capillaries.

Method: Respiratory endurance training (SpiroTiger®) was examined for the influence on oxygenation using intensified respiration. A test group with 25 healthy probands carried out two different test sequences. In the first test, the pulse and blood lactate of the probands was measured after 10 minutes of quiet reclining, 10 minutes of treadmill training and after a further 10 minutes of quiet reclining. In the second test, the same measurements were taken after 10 minutes of quiet reclining, 10 minutes of treadmill training and after 10 minutes of respiratory endurance training using AF 24 AZ/min. The hypothesis to be tested assumes there will be a significant difference in favour of the respiratory endurance training in the removal of lactate after anaerobic stress.

Preliminary Findings: The average stress on the treadmill amounted to 9.5 km/h, after which the probands showed an average pulse of 160/min and an average lactate value of 6.5 mmol/l. After the stress, the lactate reduced linearly to 4.0 mml/l after 10 minutes of quiet reclining. By using respiratory endurance training directly after the stress, the lactate reduction could be accelerated to twice the amount in half the time (5 minutes). The clear different in the removal of lactate between respiratory endurance training and the quiet reclining encourages the discussion that respiratory endurance training can improve the oxygenation of blood vessels. Whether this metabolic modification can also be transferred to tumour vessels can only be suspected at the moment. The possibility, alone, of improved oxygenation of the vessels surrounding the tumour could contribute to improved efficacy of cytostatic treatment and radiation therapy.

Figure 1 [Fig. 1]