gms | German Medical Science

27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

Expression of HPV, steroid receptors and inhibin/activin subunits in diverse parts of endometroid adenocarcinoma with squamous differentiation

Meeting Abstract

  • corresponding author presenting/speaker Stefanie Gutsche - 1. Frauenklinik, Innenstadt München, Deutschland
  • Ioannis Mylonas - 1. Frauenklinik, Innenstadt München
  • Naim Shabani - 1. Frauenklinik, Innenstadt München
  • Christina Kuhn - 1. Frauenklinik, Innenstadt München
  • Susanne Kunze - 1. Frauenklinik, Innenstadt München
  • Udo Jeschke - 1. Frauenklinik, Innenstadt München
  • Klaus Friese - 1. Frauenklinik, Innenstadt München

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPO364

The electronic version of this article is the complete one and can be found online at:

Published: March 20, 2006

© 2006 Gutsche et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Question:Endometroid adenocarcinoma with squamous differentiation are rare carcinomas of the endometrium. The aim of the examination was to determine possible pathogenetic factors and molecules, which are relevant for therapy of these tumors. We tested eight endometroid adenocarcinoma with squamous differentiation for HPV, steroid receptors and inhibin/activin-subunits.

Methods:Eight endometroid adenocarcinoma with squamous differentiation were immunohistochemically tested with specific monoclonal antibodies for HPV (polyclonal anti-HPV and monoclonal anti-HPV 18), estrogen receptor ER-α and ER-β, progesterone receptor PR-A and PR-B and the inihibin/activin subunits Inhibin-α, -βA, -βB, -βC and -βE.

Results: HPV 18 and the polyclonal HPV antibody was detected in all endometroid adenocarcinoma with squamous differentiation, both in the endometroid (n=7/8) and squamous (n=8/8) parts of the tumor. Both estrogen receptors ER-α and ER-β were not detectable in any tumor in contrast to progesterone receptor PR-A and PR-B, which were detected in about the half of these tumors: PR-A: n= 5/8 and PR-B: n= 2/8. Inhibin-α und -βB were not detected, Inhibin-βA and -βE were expressed in all these carcinoms and inhibin-βC in nearly all tumors (n=7/8).

Summary:The carcinogenesis of endometroid adenocarcinoma with squamous differentiation could be correlated with an HPV 18 infection. Adenosquamous endometrial carcinomas seem not to be controlled by estrogens. The missing expression of inhibin-α subunit suggest a tumorsuppressive function in endometroid adenocarcinomas with squamous differentiation. The missing expression of inhibin-βB subunit, which is probably a marker of differentiation, points out the malignancy of these tumors. The other inhibin subunits Inhibin-βA and βE were expressed in all and Inhibin-βC in almost all of these tumors. It remains to be seen, if it is possible to use these parameters as tumor markers.