gms | German Medical Science

27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

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HPV- infection in HIV-infected women as a tumor marker of recurrent cervical dyplasia

Meeting Abstract

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  • corresponding author presenting/speaker Andrea Gingelmaier - I. Universitätsfrauenklinik Klinikum Innenstadt, München, Deutschland
  • Thomas Grubert - Praxis, Ravensburg
  • Ralph Kästner - I. Universitätsfrauenklinik Klinikum Innenstadt, München
  • Ioannis Mylonas - I. Universitätsfrauenklinik Klinikum Innenstadt, München
  • Tobias Weissenbacher - I. Universitätsfrauenklinik Klinikum Innenstadt, München
  • Elisabeth Barthell - I. Universitätsfrauenklinik Klinikum Innenstadt, München
  • Florian Bergauer - I. Universitätsfrauenklinik Klinikum Innenstadt, München
  • Klaus Friese - I. Universitätsfrauenklinik Klinikum Innenstadt, München

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPO363

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dkk2006/06dkk473.shtml

Published: March 20, 2006

© 2006 Gingelmaier et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Background: Due to antiretroviral therapy, the life expectance of HIV positive women has been increasing substantially during the past decade. Nevertheless, cervical cancer remains an AIDS-defining disease according to CDC-classification. The evaluation of the recurrence rate of cervical dyplasia after surgical intervention and the rate of HPV persistence have been the aims of this study.

Methods: The retrospective analysis of HIV-positive women visiting our specialized outpatient clinic at a university hospital over the last 10 years included: results of every cervical cytology, cervical HPV detection (Hybrid Capture® 2 from Digene or a reverse line blot HPV-genotyping assay), cervical biopsy and/or other histology e.g cone biopsy, patient history and follow-up.

Results: From a cohort of 423 HIV-positive women, 388 had at least one in house cervical cytology. The whole cohort had a mean follow-up of 2,5 years with a mean of 8,2 outpatient visits.

HPV high-risk was at least at one examination positive for 197/344 patients (57,3%). 84/136 (61.8%) showed a persistent HPV-infection. 70/157 HIV-positive women with a cervical dysplasia received a surgical intervention to prevent cancer and 41/70 (58,6%) needed more than one operation because of recurrent dysplasia. All of the patients with a recurrency had a persistent HPV-infection. Although, 2 women developed a cervical cancer.

Conclusion: The recurrence of cervical dysplasia in HIV-positive women was very well associated with a persistent HPV-infection. Facing the high relapsing rate and the risk involved of experiencing cervical cancer HIV-positive women should be surveyed carefully using HPV-testing apart from cervical cytology.