gms | German Medical Science

27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

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Prognostic impact of micrometasases in pelvic lymph nodes in patients with carcinoma of the cervix uteri

Meeting Abstract

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  • corresponding author presenting/speaker Lars-Christian Horn - Institut für Pathologie, Abteilung Gynäko- & Perinatalpathologie, Universität Leipzig, Deutschland
  • Dana Peter - Institut für Pathologie, Abteilung Gynäko- & Perinatalpathologie, Universität Leipzig
  • Bettina Hentschel - Institut für Medizinische Informatik, Statistik und Epidemiologie, Universität Leipzig
  • Karl Bilek - Universitätsfrauenklinik Leipzig (Triersches Institut)

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPO359

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dkk2006/06dkk469.shtml

Published: March 20, 2006

© 2006 Horn et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Metastatic disease in pelvic lymph nodes is one of the major risk factors in carcinomas of the uterine cervix (CX). Contrary to breast cancer nothing is known about the prognostic impact of micrometasases (i.e. metastatic deposits < 0.2cm = pN1mic).

Pelvic lymph nodes of 266 surgically treated CX FIGO-stage IB to IIB were re-examined histologically with detailed measurement of metastatic deposits in pelvic nodes. Recurrence free and overall survival was correlated to pelvic lymph node status (pN0 vs. pN1mic vs. pN1 = metastasis > 0.2cm).

29.7% of all patients represented with pelvic lymph node involvement. 22.1% of these patients showed micrometastases (pN1mic). Patients with pN1mic represented a reduced recurrence free and overall survival compared to those without metastatic disaease (p<0.0001). There was significance when patients with pN1mich were compered to patients with macrometasases (pN1) in pelvic lymph nodes.

The results suggest that metatstatic deposits in pelvic lymph nodes are represent an important risk factor for reduced RFS and OS in cervical cancer patients, and all lymph nodes, especially resulting from sentinel lymph node procedure should be examined very careful histologically.