gms | German Medical Science

27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

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Clinical outcome of patients with metastatic papillary renal cell carcinoma

Meeting Abstract

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  • corresponding author presenting/speaker Thomas Steiner - Klinik und Poliklinik für Urologie, Friedrich-Schiller-Universität Jena, Deutschland
  • Jan Roigas - Klinik und Poliklinik für Urologie der Humbold-Universität Berlin, Campus-Charite´-Mitte
  • Hartmut Kirchner - Klinik für Innere Medizin, Kliniken Hannover - Krankenhaus Siloah
  • Christian Doehn - Klinik und Poliklinik für Urologie am Universitätsklinikum Schleswig-Holstein, Campus Lübeck
  • Hans Heynemann - Klinik und Poliklinik für Urologie der Martin-Luther-Universität Halle/Wittenberg
  • Zoltan Varga - Klinik und Poliklinik für Urologie, Phillips-Universität Marburg
  • Detlef Rohde - Klinik für Urologie, Kliniken Darmstadt
  • Michael Siebels - Klinik und Poliklinik für Urologie der Ludwig-Maximilians-Universität München
  • Jörg Schubert - Klinik und Poliklinik für Urologie, Friedrich-Schiller-Universität Jena
  • Stefan Loening - Klinik und Poliklinik für Urologie der Humbold-Universität Berlin, Campus-Charite´-Mitte
  • Dieter Jocham - Klinik und Poliklinik für Urologie am Universitätsklinikum Schleswig-Holstein, Campus Lübeck
  • Paolo Fornara - Klinik und Poliklinik für Urologie der Martin-Luther-Universität Halle/Wittenberg
  • Rainer Hofmann - Klinik und Poliklinik für Urologie, Phillips-Universität Marburg
  • Christian Stief - Klinik und Poliklinik für Urologie der Ludwig-Maximilians-Universität München

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPO295

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dkk2006/06dkk405.shtml

Published: March 20, 2006

© 2006 Steiner et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: For a long time it has been discussed, whether patients (pts.) with metastasized papillary renal cell carcinoma (mRCC pap) show special behaviour regarding the response to immuno(chemo)therapeutic options and over-all survival.

Methods: Clinical data of 59 pts. with mRCC pap were assessed at 8 treatment centres retrospectively.

Results: Median follow-up was 20 (1 – 114) months, median age at time of diagnosis was 62 (24-85) years. Men were affected predominantly (49 out of 59; 83%). 21 pts. (36%) showed metastases at time of diagnosis. In the remaining 38 pts. with metachroneous metastatic disease mean time to development of metastases was 32 (3 – 143; median 18.5) months. Sites of metastases were: pulmonary (37; 63%), osseous (24; 41%), hepatic (20; 33%), lymphatic (12; 37%). Local recurrences occurred in 17 pts. (29%). Others sites of disease were brain mts. in 6 pts. (10%), peritoneal carcinosis in 4 pts. (7%) and others. A surgical approach was performed primarily in 9 pts. (15%): pulmo 2; local recurrence and lymphomas 5; liver 1; brain 1. 26 pts. received an immuno- (interferon-a +/- interleukin-2) or immunochemotherapy (in combination with vinblastine or 5-fluorouracile) as first line treatment for metastatic disease. Overall 40 out of 59 pts. (68%) received an interferon- or interleukin-based immunotherapy. No treatment at all was performed in 12 pts. (20%) because of poor performance status. 5 out of 40 pts. (12.5%) achieved an objective response to immuno(chemo)therapy. In the Kaplan-Meier-analysis, median overall survival after diagnosis of metastatic disease was assessed to be 13 +/- 1.5 (95% Ci 9.9-16) months.

Conclusions: Clinical data of a larger population of pts. with mRCC pap have been assessed in this retrospective study for the first time. Compared to pts. with clear cell mRCC, these patients are characterized by: I) more frequent local recurrences; II) low remission rates on immuno(chemo)therapeutic approaches; III)poor prognosis regarding overall survival.