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67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie
89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie
44. Tagung des Berufsverbandes der Fachärzte für Orthopädie

11. bis 16.11.2003, Messe/ICC Berlin

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Prospective comparative study of Fusidic acid, Vancomycin and Cefuroxime, in prophylactic use in T.H.R. and T.K.R. Early results

Meeting Abstract (DGOOC 2003)

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  • corresponding author Athanasios Karageorgos - Orthopaedische Klinik der Universitaet Patras, Rio-Patras, 26500, Rio-Patras,Griechenland, Phone: 0032610-999556, 999555, Fax: 0032610-994579
  • A. Papadopoulos - Orthopaedische Klinik der Universitaet Patras, Rio-Patras, 26500, Rio-Patras,Griechenland, Phone: 0032610-999556, 999555, Fax: 0032610-994579
  • M. Tyllianakis - Orthopaedische Klinik der Universitaet Patras, Rio-Patras, 26500, Rio-Patras,Griechenland, Phone: 0032610-999556, 999555, Fax: 0032610-994579
  • E. Lambiris - Orthopaedische Klinik der Universitaet Patras, Rio-Patras, 26500, Rio-Patras,Griechenland, Phone: 0032610-999556, 999555, Fax: 0032610-994579

Deutsche Gesellschaft für Unfallchirurgie. Deutsche Gesellschaft für Orthopädie und orthopädische Chirurgie. Berufsverband der Fachärzte für Orthopädie. 67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie. Berlin, 11.-16.11.2003. Düsseldorf, Köln: German Medical Science; 2003. Doc03dguX-25

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgu2003/03dgu1085.shtml

Published: November 11, 2003

© 2003 Karageorgos et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Fragestellung

Evaluation of postoperative infections in T.H.R. and T.K.R., after randomized prophylactic use of Fusidic acid, Vancomycin and Cefuroxime and assessment of their side effects.

Methoden

From December 2000 to December 2002, 211 patients, were operated on T.H.R. and T.K.R. in Orthopaedic Department of University of Patras. Mean age was 65.8 y. The patients were categorized into three groups (A, B and C). In group A was administrated Fusidic acid 500mg and Cefuroxime 1.5g preoperatively and 2 doses of Fusidic acid 500mg postoperatively. Group B received Vancomycin 1g and Cefuroxime 1.5g preoperatively and 2 doses of Vancomycin 1g postoperatively. Group C received Cefuroxime 1.5g preoperatively and 2 doses of Cefuroxime 750mg postoperatively. Blood tests were systematically performed preoperatively, and the first and fifth postoperative day. Mean follow up was 13,5 m. (range 2-24 m.).

Ergebnisse

One patient of group B developed deep wound infection. Superficial infections developed 3 pt. (4.4%) of group A, 3 pt. (5.2%) of group B and 2 pt. (2.3%) of group C. Temperature over 38.3o C attributed to another infection site was observed in 6 pt. (8.8%) of group A, 3 pt. (5.2%) of group B and 5 pt. (5.8%) of group C. No side effect was recorded.

Schlussfolgerungen

The proper use of antibiotic prophylaxis according to pharmakokinetic and pharmakodynamic properties combined with sterile surgical techniques prevents early deep wound infections in T.H.R. and T.K.R. The use of specific antistaphylococcal agents is of no benefit in antimicrobial prophylaxis for the above operations.