gms | German Medical Science

Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizer Gesellschaft für Thoraxchirurgie

07. - 09.10.2010, Wien (Österreich)

Distinct overall survival of chromosomal clusters in NSCLC and higher chromosomal instability of squamous cell carcinoma versus adenocarcinoma – a comparative genomic hybridization study

Meeting Abstract

  • A. Emmert - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • T. Hellms - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • V. Didilis - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • M. Hinterthaner - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • A. Hockemeyer - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • L. Füzesi - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • R. Seipelt - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • B. Danner - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland
  • F. A. Schöndube - UMG, Thorax-, Herz-, Gefäßchirurgie, Göttingen, Deutschland

Deutsche Gesellschaft für Thoraxchirurgie. Österreichische Gesellschaft für Thoraxchirurgie. Schweizerische Gesellschaft für Thoraxchirurgie. Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizer Gesellschaft für Thoraxchirurgie. Wien, Österreich, 07.-09.10.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10dgtF1.2

DOI: 10.3205/10dgt008, URN: urn:nbn:de:0183-10dgt0087

Published: September 30, 2010

© 2010 Emmert et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

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Background: Lung cancer is one of the most aggressive tumours with a very low overall five year survival rate and a high recurrence rate even in lower stages. Genetic aberrations are able to detect imbalances with potential impact on prognostic and therapeutic targets.

Methods: Surgical resected non-small cell lung cancer (n=80) were retrospectively analysed by comparative genomic hybridization. To model the cytogenetic evolution, an oncogenetic tree model was reconstructed. Clinicopathologic data were compared with chromosomal imbalances and follow up (mean 42.6 months, maximum 106 months).

Results: SCC showed a higher chromosomal instability, with more three folds more aberrations than ADC did. The oncogenetic tree model identified three major cytogenetic pathways for SCC: the +3q, the -13q and +2p pathway. Except for sex, no clinicopathologic parameter was different between the three groups, but the +2p pathways was characterised with a significant better long term survival (mean mean 72.6±9.4 months versus 44.3±7.4 months, log rank p=0.046) than the other pathways, which had a distinct chromosomal pattern. For ADC two pathways differ for overall survival: the +5p pathway versus the +8q pathway (mean 57.2±10.9 months versus 14.2±4.6 months, log-rank p=0.009). As well as for SCC, clinicpathologic pattern was not different between the groups.

Conclusions: Chromosomal aberrations, detected by CGH analyses and oncogenetic tree modelling revealed distinct chromosomal pattern for SCC and ADC. Survival analyses showed pathways of chromosomal imbalances determining long term outcome.

Disclosure: No significant relationships.