gms | German Medical Science

18. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie

Deutsche Gesellschaft für Thoraxchirurgie

08.10. bis 10.10.2009, Augsburg

High serum LDH and tumour LDH-5 values are associated with poorer survival in patients with NSCLC lung cancer

Meeting Abstract

  • B. Danner - University of Göttingen, Dept. of Thoracic- and Cardiovascular Surgery, Göttingen
  • V. Didilis - University of Göttingen, Dept. of Thoracic- and Cardiovascular Surgery, Göttingen
  • S. Wiemeyer - University of Göttingen, Dept. of Thoracic- and Cardiovascular Surgery, Göttingen
  • R. Seipelt - University of Göttingen, Dept. of Thoracic- and Cardiovascular Surgery, Göttingen
  • L. Füsezi - University of Göttingen, Dept. of Thoracic- and Cardiovascular Surgery, Göttingen
  • F. Schöndube - University of Göttingen, Dept. of Thoracic- and Cardiovascular Surgery, Göttingen

Deutsche Gesellschaft für Thoraxchirurgie. 18. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie. Augsburg, 08.-10.10.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. DocFO1.6

DOI: 10.3205/09dgt53, URN: urn:nbn:de:0183-09dgt533

Published: November 20, 2009

© 2009 Danner et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Objective: Energy delivery in cancer cells is generated by glycolysis with pyruvate as an essential product which is transformed either to acetyl CoA or to lactate by lactate dehydrogenase (LDH). This competitive process is upregulated in tumorous cells for lactate production. High serum LDH value is linked in a lot of malignancies obviously to poorer survival. This correlation for NSCLC lung cancer was not investigated widely. LDH in tumour is composed mostly of LDH-5 isozyme and is linked with survival especially in gastric cancers. We investigated NSCLC lung cancer (adenocarcinoma and squamous cell carcinoma) for tumour LDH-5 expression and correlation to serum LDH-5 and survival.

Patients: In 89 patients operated on NSCLC lung cancer stage I-III (UICC 2002) the serum LDH value was given and immunohistochemistry of paraffin embedded tumour section with LDH-5 antibody was performed. Long term follow up was given with information to reasons for death.

Results: High Serum LDH was strongly associated with poorer survival overall patients. Serum LDH values were not correlated with the LDH-5 value in tumour. Only in tumours with a diameter greater of 3 cm high tumour LDH-5 value was associated with higher serum LDH values versus medium tumour LDH-5 value (229±64 U*l-1 and 182±34 U*l-1, respectivley). Over all stages there was no impact on survival for tumour LDH-5. In subgroup analysis, high tumour LDH-5 values were associated with poorer survival in positive N1 nodal status and in tumours with a diameter greater than 3 cm. On the other hand also low tumour LDH-5 values had a negative impact on survival.

Conclusion: We can describe a statistical significant impact of high tumour LDH-5 value on long term survival in positive N1 nodal status and in tumour diameter greater than 3 cm in patients operated on NSCLC adeno- or squamous cell lung cancer. A correlation of serum LDH and tumour LDH-5 values was not found, but but there is a strong impact of high serum LDH values on long term mortality.