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45. Kongress der Deutschen Gesellschaft für Rheumatologie, 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie, 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie

06.09. - 09.09.2017, Stuttgart

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Antibodies against MYC-associated Zinc Finger Protein: An Independent Marker in Acute Coronary Syndrome?

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  • Diana Ernst - Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover
  • Christian Widera - Universität Oldenburg, Kardiologie, Oldenburg
  • Niklas Baerlecken - Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover
  • Reinhold E. Schmidt - Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover
  • Wolfgang Schlumberger - EUROIMMUN Medizinische Labordiagnostika AG, Lübeck
  • Kai Christoph Wollert - Medizinische Hochschule Hannover, Kardiologie, Hannover
  • Torsten Witte - Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR). Stuttgart, 06.-09.09.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocER.18

doi: 10.3205/17dgrh096, urn:nbn:de:0183-17dgrh0966

Published: September 4, 2017

© 2017 Ernst et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Background: Atherosclerosis is considered the pathophysiology underlying cardiovascular (CVD), cerebrovascular and peripheral vascular diseases. Increasing evidence supports autoimmunity in atherosclerosis. Imaging studies have correlated MYC-associated zinc finger protein antibodies (MAZ-Ab) with atherosclerotic plaque activity. This study examines the prevalence of MAZ-Ab in patients presenting with acute coronary syndrome versus healthy controls, and their relationship to traditional cardiovascular risk factors.

Methods: Clinical data on patients admitted with proven acute coronary syndrome (ACS) between August 2007 and September 2008 was collected. Serum samples, taken at presentation were retrospectively tested for MAZ-Ab. Further serum from healthy volunteers, proven to have no CVD risk factors acted as controls.

Results: Serum MAZ-Ab was evaluated in 270 individuals, with 174/270 patients (64%) having had an ACS. Among these patients, median MAZ-Ab optical density was significantly higher compared to controls (0.27 vs. 0.46; P=0.001). While the majority of patients (116/174; 67%) in the ACS group had suffered from a ST elevation myocardial infarction, there was no significant difference in MAZ-Ab between the various ACS sub-types (P=0.682). No relationship between MAZ-Ab titre and conventional cardiovascular risk factors could be identified.

Conclusion: Patients presenting with any type of ACS demonstrated significantly higher MAZ-Ab titres than known healthy controls. Given current knowledge of MAZ-Ab function, these findings support an autoimmune component to CVD. This effect may be independent of conventional risk factors. Additionally MAZ-Ab titre appears unrelated to the extent of end-organ damage. Further research is needed to evaluate the prognostic value of MAZ-Ab as an additional risk factor for CVD.