gms | German Medical Science

48. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 55. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie (ÖGPÄRC), 22. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC)

14.09. - 16.09.2017, Graz, Österreich

Skin rejuvenation through HIF-1α upregulation – A new treatment paradigm in anti-aging medicine

Meeting Abstract

  • presenting/speaker Matthias M. Aitzetmüller - Klinikum rechts der Isar, Abteilung für experimentelle Plastische Chirurgie, München, Deutschland
  • Ursula Hopfner - Klinikum rechts der Isar, Abteilung für experimentelle Plastische Chirurgie, München, Deutschland
  • Manuela Kirsch - Klinikum rechts der Isar, Abteilung für experimentelle Plastische Chirurgie, München, Deutschland
  • Hans-Günther Machens - Klinikum rechts der Isar, Abteilung für experimentelle Plastische Chirurgie, München, Deutschland
  • Dominik Duscher - Klinikum rechts der Isar, Abteilung für experimentelle Plastische Chirurgie, München, Deutschland

Deutsche Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen. Österreichische Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie. Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen. 48. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 55. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie, 22. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC). Graz, Österreich, 14.-16.09.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. Doc196

doi: 10.3205/17dgpraec196, urn:nbn:de:0183-17dgpraec1960

Published: August 16, 2017

© 2017 Aitzetmüller et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

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Introduction: Skin changes are among the most visible signs of aging. With aging the skin thins and changes in the connective tissue reduce the skin's strength and elasticity. The blood vessels of the dermis become more fragile. This leads to bruising and impairments in the regenerative capacity of aging skin. The hypoxia-induced factor HIF-1α is a master transcription factor regulating tissue homeostasis by controlling the cellular response to stress, injury and ischemia. Studies show that aging leads to an increasing limitation of HIF-1α activity, which in turn causes chronic regeneration and wound healing disorders. Recent evidence suggests that upregulation of HIF-1α can regenerate aging skin on a molecular level. Here we present anti-aging effects linked to upregulation of HIF-1α expression through local removal of free iron in cutaneous tissue via the small molecule Deferiprone.

Methods: We characterized the effects of the iron chelator and HIF-1α activator Deferiprone on aged dermal cells in vitro via gene expression and protein analysis. Next a topical cutaneous application of Deferiprone was formulated and tested in 30 healthy volunteers in a dermatologically controlled, randomized, split face study over 6 weeks. Skin roughness, moisture, barrier function and elasticity were measured. Wrinkle severity was additionally rated by independent expert observers.

Results: Deferiprone significantly increased regenerative cytokine expression of dermal cells in vitro. In the clinical study a significant improvement of skin surface roughness, moisture and elasticity could be detected. Skin barrier function was unaffected. Expert assessment demonstrated significant wrinkle reduction.

Conclusion: The application of the iron chelator and HIF-1α activator Deferiprone resulted in rejuvenation on both the cellular and the tissue level leading to significant improvements of skin quality and appearance without any signs of irritation.