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44. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen e. V. (DGPRÄC), 18. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen e. V. (VDÄPC)

12.09. - 14.09.2013, Münster

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Severe posttraumatic radiocarpal cartilage damage: First report of autologous chondrocyte implantation

Meeting Abstract

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  • presenting/speaker Fabian Medved - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland
  • Phillipp Gonser - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland
  • Oliver Lotter - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland
  • Jens Rothenberger - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland
  • Amro Amr - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland
  • Dirk Albrecht - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland
  • Afshin Rahmanian-Schwarz - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland
  • Hans-Eberhard Schaller - BG Unfallklinik Tübingen, HPRV, Tübingen, Deutschland

Deutsche Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen. Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen. 44. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 17. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC). Münster, 12.-14.09.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocP 70

doi: 10.3205/13dgpraec172, urn:nbn:de:0183-13dgpraec1721

Published: September 10, 2013

© 2013 Medved et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Clinical question: Traumatic articular cartilage defects predispose to secondary osteoarthritis accompanied by impairment or complete loss of function in the corresponding joint. On this account the timely and correct diagnosis as well as the selection of an appropriate therapy for reconstruction of articular cartilage defects is important.

Methods: A 22-year-old healthy male patient with history of traumatic intra-articular distal radius fracture is presented with in the course detectable 4° cartilage damage in the fovea scaphoidea and into the fovea lunata. For the first time autologous chondrocyte implantation by the use of an in-situ polymerizable albumin-hyaluronic acid gel was performed to restore the articular cartilage.

Results: The assessment 6 month after autologous chondrocyte implantation using the standard DASH questionnaire for upper extremity pointed out an improvement in the patient outcome. The clinical examination also showed a bonification of the range of movement of the wrist without pain (Figure 1 [Fig. 1]). The radiological control investigation (MRI- examination) of the wrist 6 month after implantation also revealed a good integration of the implant (Figure 2 [Fig. 2]).

Conclusion: The case presented here demonstrates the first use of autologous chondrocyte implantation for cartilage reconstruction by using an in situ polymerizable albumin-hyaluronic acid gel after traumatic cartilage lesion with 4° cartilage damage of the wrist in a 22-year-old non-smoking, active and healthy man. Initial results are promising in terms of mobility, pain and patient outcome. However, further clinical studies have to be performed with larger number of cases.