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57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

German Society for Neuropathology and Neuroanatomy

12. - 15.09.2012, Erlangen

57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

Cortical dysplasia:Clinical work-up and neuropathological findings in a drug resistant epilepsy case.

Meeting Abstract

  • presenting/speaker María Francisca Tristán Agundis - Hospital Psiquiátrico "Fray Bernardino Álvarez", Patología, Mexico DF, Mexico
  • Gustavo Vargas Félix - Universidad La Salle., Facultad Mexicana de Medicina, Mexico DF, Mexico
  • Daniel Sebastián Totxo Guerrero - Universidad Nacional Autónoma de México., Facultad de Medicina, Mexico DF, Mexico
  • Josefina Sandoval Paredes - Instituto Nacional de Neurología y Neurocirugía, Neuroimagen, Mexico DF, Mexico
  • Silvia Gabriela Macías Arriaga - Instituto Nacional de Neurología y Neurocirugía, Neuroimagen, Mexico DF, Mexico
  • Rosa Emma Alonso Zúñiga - Universidad Autónoma de San Luis Potosí., Facultad de Medicina, Mexico DF, Mexico
  • Brenda Peralta Rodríguez - Instituto Nacional de Neurología y Neurocirugía, Neuropatología, Mexico DF, Mexico
  • Nohemí Gelista Herrera - Instituto Nacional de Neurología y Neurocirugía, Neuropatología, Mexico DF, Mexico
  • Daniel Rembao Bojórquez - Universidad Nacional Autónoma de México., Facultad de Medicina, Mexico DF, Mexico

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Erlangen, 12.-15.09.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12dgnnPP6.8

DOI: 10.3205/12dgnn119, URN: urn:nbn:de:0183-12dgnn1195

Published: September 11, 2012

© 2012 Tristán Agundis et al.
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Outline

Text

22 year old male with record of premature membrane rupture birth, obtained by caesarean operation due to fetal distress, mild traumatic brain injury at the age of 7 and poor school performance. At the age of 8 starts with simple partial motor seizures of the right arm that progress to generalized myoclonic seizures, treated with oxcarbazepine 600mgt.i.d.and levetiracetam 500 mg q.d. showing bad response to treatment. EEG report focal mild dysfunction in left temporal and occipital areas. MRI shows dysplasia in temporal and parietal areas with hypointensity on T1 secuence, and hyperintensity on T2 weighted and FLAIR images and polymicrogyric patterns. He was submitted to surgical section of the left parietal cortex; the histopathological study reveals hypoxic areas, difuse microinfarctions, engrossment of the cortical region with eosinophylic neurons, vacuolated neuropil and slight gliosis. After surgery he persists with partial sensitive crisis of the right arm wich had remitted with oxcarbazepine 600 mg b.i.d. and levetiracetam 500 mg b.i.d. Currently the patient has a satisfactory evolution with no seizures or any neurological focal signs.