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57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

German Society for Neuropathology and Neuroanatomy

12. - 15.09.2012, Erlangen

57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

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Neuroprotective effect of erythropoietin

Meeting Abstract

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  • presenting/speaker Yasuo Iwasaki - University, Neurology, Tokyo, Japan

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Erlangen, 12.-15.09.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12dgnnPP4.3

doi: 10.3205/12dgnn080, urn:nbn:de:0183-12dgnn0801

Published: September 11, 2012

© 2012 Iwasaki.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Erytropoietin (EPO) is a hematopoitic factor which regulates committed lineage-specific progenitor. EPO and its receptor are expressed in the human brain tissues. EPO is neuroprotective not only cerebral ischemia but excite toxin and neuroinflammation. Whether EPO protects spinal motor neuron death against glutamate and axotomy induced spinal motor neuron death in the spinal motor neurons. EPO prevented not only glutamate- but also axotomy-induced neuronal death in the spinal motor neusons. There are no relationship between dose of EPO and protective effects in both studies. Amyotrophic lateral sclerosis (ALS) is characterized by death of spinal motor eurons and our results show that EPO may be one of candidate of therapeutic strategy in ALS. Further study in EPO with ALS is needed.