gms | German Medical Science

65th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

11 - 14 May 2014, Dresden

Extent of isofluran induced vasodilatation in different arterial regions of the rat

Meeting Abstract

  • Markus Bruder - Klinik für Neurochirurgie, Goethe Universität Frankfurt am Main
  • Jürgen Konczalla - Klinik für Neurochirurgie, Goethe Universität Frankfurt am Main
  • Erdem Güresir - Klinik für Neurochirurgie, Universitätsklinikum Bonn
  • Volker Seifert - Klinik für Neurochirurgie, Goethe Universität Frankfurt am Main
  • Hartmut Vatter - Klinik für Neurochirurgie, Universitätsklinikum Bonn

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocDI.11.05

doi: 10.3205/14dgnc180, urn:nbn:de:0183-14dgnc1808

Published: May 13, 2014

© 2014 Bruder et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Isofluran is a volatile anaesthetic inducing vasodilatation and increasing the cerebral blood flow. In addition with a neuroprotecitve effect, isofluran seems to be promising for the treatment of subarachnoid haemorrhage patients who are at risk for vasospasm. The effect of isofluran on the blood flow of different organs is very variable, as shown in animal studies. In this study we analysed the extent of vasodilatation induced by isofluran in five different vascular regions.

Method: Rings of the femoral-, the renal-, the supra mesenteric-, the pulmonal- and the basilar artery of 18 male Sprague-Dawley-rats were placed into organ bath chambers for isometric force measuring. To analyse the effect of the endothelium, it was destroyed in half of the arterial rings (E- vessels). After contracting the artery rings with 62mMol-potassium-solution, isofluran was injected into the organ bath chambers in rising concentration up to 4.5Vol% in 0.5Vol% steps. Vasodilatation was measured as a loss of contraction with an isometric force transducer.

Results: Isofluran induced an significant vasodilatation with every concentration used. The maximum relaxing effect was 44.6% in mean of the initial contraction force. CECs did not differ between E+ or E- vessels. Comparing the five different arterial regions, there was no significant difference of the maximum relaxing effect (Emax). The EC50-value of the femoral artery was significantly higher than the EC50-value of the superior mesenteric artery (2.22 (± 0.28) vs. 2.74 (± 0.11); p=0.002). There was no significant difference of the EC50-values between the other arteries.

Conclusions: Isofluran induces a significant vasodilatation of the femoral- , the renal- , the supra mesenteric- , the pulmonal- and the basilar artery already in low concentrations. The maximum extent of vasodilatation did not differ between the tested arteries. The endothelium had no effect on the isofluran induced vasodilatation in this study.