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64th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

26 - 29 May 2013, Düsseldorf

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Preoperative grading of pure oligodendroglial brain tumors using 18F-FDG and FET positron emission tomography (PET)

Meeting Abstract

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  • Andreas Merkel - Department of Neurosurgery, University of Erlangen-Nuremberg
  • Michael Zoller - Academic Teaching Hospital, Feldkirch, Austria
  • Alexander Becherer - Academic Teaching Hospital, Feldkirch, Austria
  • Manfred Cejna - Academic Teaching Hospital, Feldkirch, Austria
  • Michael Buchfelder - Department of Neurosurgery, University of Erlangen-Nuremberg
  • Karl Roessler - Department of Neurosurgery, University of Erlangen-Nuremberg

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocMO.10.08

doi: 10.3205/13dgnc087, urn:nbn:de:0183-13dgnc0870

Published: May 21, 2013

© 2013 Merkel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: PET using 18F FET (fluoroethyl-L-tyrosine) and 18F-FDG (fluoro- desoxyglucose) are widely used for non-invasive preoperative grading of glial brain tumors. However, the correlation of FDG and amino acid PET uptake with histological grade in pure oligodendrogliomas is discussed controversially. Thus, we retrospectively investigated this relationship in patients suffering from pure oligodendrogliomas

Method: Altogether, twelve patients (8 female, 4 male, mean age 37, from 21–69) surgically treated during the last 4 years had pure oligodendrogliomas. Preoperative 18F-FET PET and 18F-FDG PET uptake areas were correlated to the histological grading of intraoperatively collected tissue samples during resection using image fusion and navigation.

Results: Out of 12 patients harboring pure oligodendrogliomas, 5 were graded as low-grade tumors (WHO II) and 7 as anaplastic tumors (WHO III). All tumors but one (11/12) had a strong FET uptake, irrespective of the histological grade. Standard uptake values (SUV) of grade II tumors were 1.5 mean (1.3–1.7), in grade III tumors 2.1 mean (1.6–2.6), differences not significant (p=0.06). Only one oligodendroglioma III showed FDG uptake, 6 out of 7 anaplastic oligodendrogliomas (grade III) and all low-grade tumors were FDG negative.

Conclusions: Pure oligodendrogliomas in our series demonstrated strong FET uptake, irrespective of the histological grading, whereas FDG PET was not useful in separating high-grade pure oligodendrogliomas from low-grade tumors.