gms | German Medical Science

62nd Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Polish Society of Neurosurgeons (PNCH)

German Society of Neurosurgery (DGNC)

7 - 11 May 2011, Hamburg

Expression and up-regulation of coagulation factors and their receptors in tumor tissue and peripheral blood of patients with cerebral meningiomas

Meeting Abstract

Search Medline for

  • S. Kuhn - Neurochirurgische Klinik, Klinikum der Friedrich-Schiller-Universität, Jena, Deutschland
  • L. Handel - Neurochirurgische Klinik, Klinikum der Friedrich-Schiller-Universität, Jena, Deutschland
  • R. Kalff - Neurochirurgische Klinik, Klinikum der Friedrich-Schiller-Universität, Jena, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocMI.04.11

DOI: 10.3205/11dgnc209, URN: urn:nbn:de:0183-11dgnc2092

Published: April 28, 2011

© 2011 Kuhn et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Objective: Patients with meningiomas may suffer from thrombembolic complications or bleeding into the tumor resection cavity. Clear reasons for these complications are not known to date.

Methods: Twenty tumor samples of intracranial meningiomas each (WHO I°, WHO II°, and WHO III°) were analyzed immunohistochemically for the expression of the coagulation factors II/IIa and X/Xa as well as for the expression of the protease-activated receptors type 1, 2, 3, and 4. In addition, patients with intracranial meningiomas WHO I° and WHO II° were included in a prospective case-controlled study and correlated to control patients with lumbar disc herniations. Their blood was collected one day before and one and four days after tumor surgery and investigated for the activity of the coagulation factors II, V, VII, VIII, IX, X, XI, XII and XIII, as well as for the activity of antithrombin III, and the concentrations of the d-dimers and of fibrinogen.

Results: Human meningiomas displayed tumor-specific expression patterns of coagulation factors and their receptors when compared to the formerly collected expression data of human gliomas or brain metastases. Whereas the PAR1 and PAR2 were found at low levels, PAR3 and PAR4 were strongly expressed in human meningiomas, even rising with the WHO grade. Prothrombin and thrombin were also expressed in meningioma cells and are known for different actions at the PARs 3 and 4 in comparison to the PARs 1 and 2. In addition, patients with intracranial meningiomas show an up-regulation of the coagulation factors II and IX and a down-regulation of the coagulation factor XIII in their peripheral blood.

Conclusions: This study shows the different expression patterns of coagulation factors and their receptors in human meningiomas and the distinct activation and inactivation patterns of the peripheral coagulation factors II, IX, and XIII. Patients with thrombembolic events may often display an activation of the factors II and IX, whereas patients with intratumoral or postoperative bleeding may have reduced factor XIII levels.