gms | German Medical Science

62nd Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Polish Society of Neurosurgeons (PNCH)

German Society of Neurosurgery (DGNC)

7 - 11 May 2011, Hamburg

Early CT perfusion measurement after aneurysmal subarachnoid hemorrhage as a possible predictor for the outcome?

Meeting Abstract

  • H.J. Heiroth - Klinik für Neurochirurgie, Heinrich-Heine-Universität, Düsseldorf
  • M. Kamp - Klinik für Neurochirurgie, Heinrich-Heine-Universität, Düsseldorf
  • N. Etminan - Klinik für Neurochirurgie, Heinrich-Heine-Universität, Düsseldorf
  • B. Turowski - Institut für Radiologie, Heinrich-Heine-Universität, Düsseldorf
  • H.J. Steiger - Klinik für Neurochirurgie, Heinrich-Heine-Universität, Düsseldorf
  • D. Hänggi - Klinik für Neurochirurgie, Heinrich-Heine-Universität, Düsseldorf

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocDI.10.06

DOI: 10.3205/11dgnc170, URN: urn:nbn:de:0183-11dgnc1708

Published: April 28, 2011

© 2011 Heiroth et al.
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Outline

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Objective: The outcome of patients after aneurysmal subarachnoid hemorrhage (SAH) is mainly determined by the initial neurological impairment which seems to depend highly on immediate hypoperfusion. Thus, in the present study, the initial early perfusion in patients with SAH was investigated with respect to their neurological outcome.

Methods: In the present series 35 patients with SAH were studied with an early CT-based perfusion measurement that was performed within the first 12 hours after initial bleeding. In all patients the mean transit time (MTT), the time to peak (TTP), the cerebral blood flow (CBF) and the cerebral blood volume (CBV) were recorded and analyzed. The results were correlated with the initial clinical status according to WFNS and the Glasgow Outcome Scale (GOS) at the time of discharge.

Results: The MTT correlated significantly with the initial WFNS scale and the GOS at time of discharge. The MTT of the right hemisphere in WFNS°I patients (n=13) was 3.2s (± 0.6), WFNS°II-III (n=8) 4.2 s (± 0.3) and in WFNS°IV-V (n=14) 4.6 s (± 0.4) whereas the MTT on the left in WFNS°I patients was 3.3 s (± 0.4), in WFNS°II-III patients 4.1 s (± 0.6) and in WFNS°IV-V patients 4.8 s (± 0.6). Further parameters did not show a significant correlation.

Conclusions: The results of the present study confirm the latest findings of our pilot series that the MTT seen in early CT-perfusion measurement correlates significantly with the initial neurological grading and the clinical outcome in patients suffering from SAH. Therefore the initial MTT can be considered as a reliable predictor of CT-perfusion.