gms | German Medical Science

62nd Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Polish Society of Neurosurgeons (PNCH)

German Society of Neurosurgery (DGNC)

7 - 11 May 2011, Hamburg

SIOP choroid plexus tumor study 2000 update

Meeting Abstract

  • U. Kordes - University of Hamburg, Germany
  • T. Kutluk - Hacettepe University, Ankara, Turkey
  • M. Hasselblatt - University of Muenster, Germany
  • A. Mahajan - MDAnderson Cancer Center, Houston, United States
  • T. Pietsch - University of Bonn, Germany
  • P. Thall - MDAnderson Cancer Center, Houston, United States
  • J.E. Wolff - Floating Hospital, Tufts Univeristy, Boston, United States

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocDI.07.02

DOI: 10.3205/11dgnc146, URN: urn:nbn:de:0183-11dgnc1467

Published: April 28, 2011

© 2011 Kordes et al.
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Outline

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Objective: Presentation of the updated interim analyis of the CPT-SIOP-2000 study

Methods: Interim analyis of the CPT-SIOP-2000 study

Results: Very rare tumors such as choroid plexus tumors require large referral populations to generate meaningful clinical data. In the year 2000, the international Society of Pediatric Oncology, SIOP started a program including a prospective registry, a standard of care recommendation, and a randomized treatment protocol (CPT-SIOP-2000). Data of 188 tumors were registered by February 2010 from 173 patients, 15 of whom had two subsequent tumors documented. 83 of these patients were registered from Germany. 84 were male, the mean age was 4.1 years (range 0.1–45), 57 had choroid plexus papilloma, 48 atypical choroid plexus papilloma, and 57 choroid plexus carcinoma, 10 histologies could not be classified. 39.1% were located in each of the lateral ventricles, 6.1% in the third ventricle, 11.7% in the fourth ventricle, 1.8% in the CP-angle, and 1.2% had multiple locations. Complete resection was achieved in 75.5%. The 5-year OS of 163 patients with classified histology was 84.5% (SE 4.4%), and 5Y-EFS was 65.1 (SE 5.4%). The prognostic relevance of the histology and radiation was confirmed as previously described. However, the prognostic relevance of surgical resection disappeared when covariates of histology and radiation were used in COX regression analyses.

Conclusions: Two chemotherapy protocols (analyzed as blinded dataset) did not differ in outcome results, but the final analysis is not planned until 2015.