gms | German Medical Science

61st Annual Meeting of the German Society of Neurosurgery (DGNC) as part of the Neurowoche 2010
Joint Meeting with the Brazilian Society of Neurosurgery on the 20 September 2010

German Society of Neurosurgery (DGNC)

21 - 25 September 2010, Mannheim

The genetic progression score (GPS) in meningiomas by FISH as an impartial marker for tumor recurrence

Meeting Abstract

  • Stefan Linsler - Neurochirurgische Klinik, Universität des Saarlands, Homburg/Saar, Germany
  • Silke Wemmert - Klinik für Otolaryngologie, Universität des Saarlands, Homburg/Saar, Germany
  • Jörg Rahnenführer - Fakultät Statistik, Technische Universität Dortmund, Germany
  • Wolf-Ingo Steudel - Neurochirurgische Klinik, Universität des Saarlands, Homburg/Saar, Germany
  • Steffi Urbschat - Neurochirurgische Klinik, Universität des Saarlands, Homburg/Saar, Germany
  • Ralf Ketter - Neurochirurgische Klinik, Universität des Saarlands, Homburg/Saar, Germany

Deutsche Gesellschaft für Neurochirurgie. 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010. Mannheim, 21.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. DocP1735

DOI: 10.3205/10dgnc206, URN: urn:nbn:de:0183-10dgnc2066

Published: September 16, 2010

© 2010 Linsler et al.
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Outline

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Objective: Meningiomas are tumors that arise from the coverings of the brain or the spinal cord. They are mostly benign and can often be surgically cured. However, in about 8% of the cases, an increased risk of tumor recurrence and a more aggressive clinical behavior is observed. Cytogenetically, meningiomas are well characterized with either a normal karyotype or monosomy of chromosome 22 in most of the tumors. Clinically relevant are the most common losses of the autosomes 1p, 9p, 14 and 18. The order of accumulating genetic aberrations has previously been estimated with oncogenetic tree models, and a genetic progression score (GPS) derived from these models was shown to be more predictive for tumor recurrence than the WHO classification.

Methods: 50 meningioma patients were operated by open surgery between 2008 and 2010. Tissue specimens from tumors were obtained after surgery and prepared for FISH analysis. In accordance with our previous results, we used two color FISH for chromosomal alterations of chromosome 1, 9, 14, 18 and 22.

Results: In our cohort 52% (26/50) correspond to WHO I, 40% (20/54) to WHO II and 8% (4/50) to WHO III meningiomas. The average age of all patients was 59,6 years (±11,4). It was 58,5 years (±11,4) for the female patients (32/50) and 63,4 years (±15,1) for the male patients (18/50). FISH analyses were performed in these 50 cases and for each meningioma up to 200 nuclei were evaluated. In 32 tumors we found deletions of chromosome 22. In 22 cases the deletion of the short arm of chromosome 1 was detectable. Losses of chromosome 14 were found in 13 cases, of chromosome 18 in 6 cases and of 9p in 4 cases. Based of these results, 27 cases correspond to a GPS ≤1, 6 cases to a GPS ≥1 and <6,02 and 17 cases ≥6,02 indicating a higher risk of tumor recurrence.

Conclusions: Grading and prognostic assessment of meningiomas can be controversial. Obviously the biological behavior of meningiomas can not be reflected in histological parameters alone. Cytogenetic characterization of meningiomas by FISH analysis or by karyotyping can provide an insight into their potential of recurrence by GPS classification and are therefore a valuable criterion for the neurosurgeon's postoperative management protocol.