gms | German Medical Science

61st Annual Meeting of the German Society of Neurosurgery (DGNC) as part of the Neurowoche 2010
Joint Meeting with the Brazilian Society of Neurosurgery on the 20 September 2010

German Society of Neurosurgery (DGNC)

21 - 25 September 2010, Mannheim

Recurrence in cranio-cervical meningiomas – regrowth of residual tumor or atypical subtype of meningioma?

Meeting Abstract

  • Pedram Emami - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
  • Jan Regelsberger - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
  • Jakob Matschke - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
  • Manfred Westphal - Neurochirurgische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Deutsche Gesellschaft für Neurochirurgie. 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010. Mannheim, 21.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. DocP1730

doi: 10.3205/10dgnc201, urn:nbn:de:0183-10dgnc2014

Published: September 16, 2010

© 2010 Emami et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Meningioma of the cranio-cervical junction demands thorough surgical planning as the radical excision of these tumors, especially of the anterior portions, may be limited. Recurrence is therefore believed to be most likely due to the regrowth of residual tumor. By now histological analyses for this subgroup have not been correlated with their clinical course and this probably explains an unusual high recurrence rate.

Methods: From our single institution databank 20 patients with cranio-cervical meningioma (foramen magnum and C0-C2) operated on between 1997 and 2009 were found and analyzed for their clinical data, histology and MIB-1 immunoreactivity.

Results: There were 15 female and 5 male patients aged 26–79 years (mean 58.8yrs). According to the WHO-grading, all tumors were found to be grade I. Histological subtypes included meningotheliomatous (15), transitional (3) and fibrocytic (2) meningiomas. MIB-1 labeling index (range between 1.5–31%) was found to be elevated (15.3%) significantly when compared to an age and gender matched control group (4.6%). Recurrence was seen in two cases after 3 and 8 years but was not related to incomplete resection, their histological results and MIB-1 data.

Conclusions: High MIB-1 levels in meningiomas of the cranio-cervical junction are striking in our study group. Therefore immunochemistry and incomplete resection may both be important factors influencing the clinical course. We regard cranio-cervical meningiomas as a distinctive subgroup of meningioma due to their high MIB-1 levels and their surgically challenging location.