gms | German Medical Science

61st Annual Meeting of the German Society of Neurosurgery (DGNC) as part of the Neurowoche 2010
Joint Meeting with the Brazilian Society of Neurosurgery on the 20 September 2010

German Society of Neurosurgery (DGNC)

21 - 25 September 2010, Mannheim

Stimulated functional brain areas can be visualized by optical imaging of intrinsic signals during brain surgery

Meeting Abstract

  • Stephan B. Sobottka - Klinik für Neurochirurgie, Universitätsklinikum Dresden, Deutschland
  • Tobias Meyer - Institut für Biomedizinische Technik. Technische Universität Dresden, Deutschland
  • Matthias Kirsch - Klinik für Neurochirurgie, Universitätsklinikum Dresden, Deutschland
  • Mario Leimert - Klinik für Neurochirurgie, Universitätsklinikum Dresden, Deutschland
  • Edmund Koch - Klinisches Sensoring und Monitoring, Technische Universität Dresden, Deutschland
  • Ralf Steinmeier - Klinik für Neurochirurgie, Klinikum Chemnitz gGmbH, Deutschland
  • Ute Morgenstern - Institut für Biomedizinische Technik, Technische Universität Dresden, Deutschland
  • Gabriele Schackert - Klinik für Neurochirurgie, Universitätsklinikum Dresden, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010. Mannheim, 21.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. DocV1573

doi: 10.3205/10dgnc048, urn:nbn:de:0183-10dgnc0481

Published: September 16, 2010

© 2010 Sobottka et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Optical imaging of intrinsic signals is a new method for a fast and contact free visualization of stimulated eloquent brain areas during neurosurgical interventions.

Methods: The intensity of the light reflected by the cortical tissue was measured in 28 patients with lesions around the somatosensory, visual or speech cortex using a high resolution camera mounted to an operating microscope. Using adequate stimulation methods the difference in the spectral absorption was used to differentiate between activated and non-activated brain areas. The data acquisition time was 9 minutes with alternating 30 seconds with and without stimulation. The difference between averaged frames was calculated and overlaid over an image of the operative site. Brain movements associated with heartbeat and respiration were compensated using a deformable registration algorithm.

Results: Localized activation of cortical tissue could be visualized for the somatosensory, visual and speech cortex. An excellent imaging quality could be achieved in most of the patients. The calculated location and the size of the activated region corresponded to anatomical landmarks, the results derived by electrophysiological examinations and confirmed the estimation of the neurosurgeon. The results were reproducible in independent examinations. In very few cases no activation of cortical tissue could be deciphered because of technical and biological artifacts.

Conclusions: Optical imaging of intrinsic signals provides an intraoperative high spatial resolution image of brain surface activation, allowing the localization of eloquent brain areas during surgery.

The study is funded by the Carl Zeiss Surgical GmbH.