gms | German Medical Science

61st Annual Meeting of the German Society of Neurosurgery (DGNC) as part of the Neurowoche 2010
Joint Meeting with the Brazilian Society of Neurosurgery on the 20 September 2010

German Society of Neurosurgery (DGNC)

21 - 25 September 2010, Mannheim

Radiosurgery for cavernous sinus meningiomas: outcomes from over 1,000 tumors

Meeting Abstract

  • Antonio Santacroce - Abteilung für Neurochirurgie Heinrich Heine Universität Düsseldorf, Deutschland; Gamma Knife Zentrum Krefeld, Deutschland
  • Gerhard A. Horstmann - Gamma Knife Zentrum Krefeld, Deutschland
  • A. T. van Eck - Gamma Knife Zentrum Krefeld, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010. Mannheim, 21.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. DocV1553

doi: 10.3205/10dgnc030, urn:nbn:de:0183-10dgnc0309

Published: September 16, 2010

© 2010 Santacroce et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Cavernous Sinus Meningioma is the most frequent benign tumor treated with Gamma Knife Radiosurgery; however the assessment of its efficacy and safety in slow growing tumors is an ongoing process, requiring analysis of long-term results. This study involves the experience of several European Gamma Knife Centres. We report on the efficacy of GKRS for the treatment of meningiomas, clinical and radiological control and side effects.

Methods: This report reviews retrospectively the material drawn from a cohort of over 1,000 benign meningiomas treated with GKRS. A visit of the centres recruited was performed by the first Author. A descriptive analysis is presented.

Results: 1,222 patients harbouring exactly 1,272 meningiomas treated in fifteen institutions recruited were evaluated. The median age was 54 years (range 6–89 years). The median tumour volume was 7.90 ccm (range 0.5–56.4 ccm). The median tumor margin dose to the 50% isodose line was 14.2 Gy (range 4–45Gy). The median radiological follow-up was 61 months The detailed results from 1115 meningiomas (87.7%) were available for analysis. The volume of treated tumors decreased in 613 lesions (55%) did not change in 433 lesions (39%) and increased in 70 lesions (6%). The temporary morbidity rate after GKRS was 4.9% and the permanent morbidity rate was 5.3%. The actuarial control rate was 97.6% at 5 years post GKRS.

Conclusions: GKRS is a safe and not invasive method of treatment of meningiomas and the large number analysed confirms a high tumor control and low morbidity rate even after a long-term follow-up period.