gms | German Medical Science

58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. bis 29.04.2007, Leipzig

Structured data assessment in patients with traumatic brain injury and aneurysmal subarachnoid hemorrhage – an interdisciplinary study concept

Strukturierte Datenerfassung zur Hypophyseninsuffizienz bei Patienten nach Subarachnoidalblutung und Schädel-Hirn-Trauma – eine interdisziplinäre Studienvorstellung

Meeting Abstract

  • corresponding author I. Kreitschmann-Andermahr - Neurochirurgische Klinik, Universitätsklinikum der RWTH Aachen
  • Y. Langejuergen - Neurochirurgische Klinik, Universitätsklinikum der RWTH Aachen
  • M. Buchfelder - Neurochirurgische Klinik, Universitätsklinikum Erlangen
  • B. Saller - EndoScience GmbH, München
  • E. Koenig - Neurologische Klinik, Bad Aibling
  • M. Jordan - ClinSupport GmbH, Erlangen
  • G. K. Stalla - Max-Planck-Institut für Innere Medizin/Endokrinologie und klinische Chemie, München

Deutsche Gesellschaft für Neurochirurgie. 58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC). Leipzig, 26.-29.04.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. DocFR.06.06

The electronic version of this article is the complete one and can be found online at:

Published: April 11, 2007

© 2007 Kreitschmann-Andermahr et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Within the last years, it has been established that neuroendocrine dysfunction is a far more frequent sequel of traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) than has formerly been estimated. However, epidemiological data on the prevalence and incidence of hypopituitarism after TBI and SAH in the general population do not exist. Moreover, very little is known about risk factors and clinical characteristics of pituitary impairment after brain damage. This lack of information might contribute to the fact that clinical and/or laboratory screening for endocrine dysfunction is still not routinely performed in TBI and SAH survivors with potentially severe consequences for the affected patients.

Methods: In order to shed more light on these open issues, a multi-center, structured data assessment to create a national registry of these patients was established in 2005. It is coordinated by the Department of Endocrinology, Max-Planck-Institute in Munich with participation of neurosurgical, rehabilitation and endocrinological centers in all of Germany (11 active centers at present). Data are collected using a structured, internet-based study sheet, obtaining information on clinical, radiological and hormonal parameters which include i.e. information on type and severity of brain injury, length of hospitalization, outcome and life situation. The database aims to connect clinical information on trauma and presence and type of hypopituitarism.

Results: At the first data close in November 2006, more than 500 patients with TBI (n=322) or SAH (n=178) had been included of whom clinical data and basal hormone values are available. In 112 TBI patients (34.8%) and 46 SAH patients (25.4%) additional endocrine function testing has been performed.

Conclusions: This conference contribution aims to make the data base, which is open to any disciplines treating patients with brain damage (including rehabilitation units, neurologists, neurosurgeons, endocrinologists, and general practitioners) more public and to present the scientific results of the first data close. The authors present this database on behalf of all participating centers.