gms | German Medical Science

58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. bis 29.04.2007, Leipzig

Serial diffusion and perfusion MRI analysis of the perihemorrhagic zone in an experimental rat ICH model: Effect of stereotactic hematoma evacuation with rt-PA

Serielle Analyse der perihämorrhagische Zone im Tiermodell mittels diffusions- und perfusions-MRT: Effekte der stereotaktischen Evakuation

Meeting Abstract

  • corresponding author B. Orakcioglu - Neurochirurgische Klinik, Universitätsklinikum Heidelberg
  • K. Becker - Neurologische Klinik, Universitätsklinikum Heidelberg
  • O. W. Sakowitz - Neurochirurgische Klinik, Universitätsklinikum Heidelberg
  • T. Steiner - Neurologische Klinik, Universitätsklinikum Heidelberg
  • A. Unterberg - Neurochirurgische Klinik, Universitätsklinikum Heidelberg
  • P. D. Schellinger - Neurologische Klinik, Klinikum der Universität Erlangen-Nürnberg, Erlangen

Deutsche Gesellschaft für Neurochirurgie. 58. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC). Leipzig, 26.-29.04.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. DocDO.01.10

The electronic version of this article is the complete one and can be found online at:

Published: April 11, 2007

© 2007 Orakcioglu et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: An MRI evaluation of rMTT and ADC in the perihematomal zone(PHZ) of intracerebral hemorrhages (ICH) in rats was performed. Animals were examined within 3.5 hours after hemorrhage. Additionally, we investigated the effect of stereotactic evacuation of the hematoma after rt-PA induced lysis.

Methods: A 2.5T MRI compatible setup for rats in a double injection model was used to produce ICH with autologous arterial blood in the basal ganglia of 49 animals. Animals were divided into 2 groups; controls (gr1, n=27) and hematoma evacuation with rtPA after the first of 3 imaging time points (gr2, n=22). DWI and PWI sequences were generated. Diffusion (rADC) and perfusion (rMTT) characteristics were analyzed in 3 regions of interest surrounding the hematoma (ROI1-3).

Results: ADC map measurements based on DWI did not demonstrate ischemia but vasogenic edema in the PHZ of ICH. Mean rADC values in ROI1 and ROI2 ranged between 1.05 to 1.18 in both groups signifying vasogenic edema. Mean rADC values in ROI3 did not show any significant changes. A non-significant perfusion reduction was confirmed in comparison to the healthy hemisphere in the periphery (ROI1) and outer rim (ROI2). Mean rMTT values in ROI 1 were 1.1(gr1) vs. 1.09(gr2) at TP1, 1.06(gr1) vs. 0.97(gr2) at TP2 and 1.27(gr1) vs. 1.02(gr2) at TP3; in ROI2 rMTT values were 1.06(gr1) vs. 1.07(gr2) at TP1, 1.05(gr1) vs. 1.02(gr2) at TP2 and 1.16(gr1) vs. 0.97(gr2) at TP3. ROI3 did not show rMTT changes in both groups.

Conclusions: We demonstrate vasogenic edema and a non-significant perfusion reduction without ischemia in the PHZ as measured by MRI after ICH. The existence of a perihemorrhagic “penumbra” analogous to ischemic stroke is unlikely.