gms | German Medical Science

57th Annual Meeting of the German Society of Neurosurgery
Joint Meeting with the Japanese Neurosurgical Society

German Society of Neurosurgery (DGNC)

11 - 14 May, Essen

Growth and de novo generation of cavernous malformations

Wachstum und Neubildung von zerebralen kavernösen Malformationen

Meeting Abstract

  • corresponding author O. Sürücü - Neurochirurgische Klinik, Philipps-Universität, Marburg
  • L. Benes - Neurochirurgische Klinik, Philipps-Universität, Marburg
  • O. Bozinov - Neurochirurgische Klinik, Philipps-Universität, Marburg
  • D. Miller - Neurochirurgische Klinik, Philipps-Universität, Marburg
  • H. Bertalanffy - Neurochirurgische Klinik, Philipps-Universität, Marburg
  • U. Sure - Neurochirurgische Klinik, Philipps-Universität, Marburg

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocSA.11.02

The electronic version of this article is the complete one and can be found online at:

Published: May 8, 2006

© 2006 Sürücü et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Cerebral cavernous malformations (CCM) are considered to be congenital and static malformations. On the other hand, the potential of growth and de novo generation of CCM have been reported. It was therefore of interest to study the proliferative and neoangiogenetic capacity of these lesions.

Methods: The surgical specimens of 56 CCM (23 deep, 33 superficial) from adult patients and 19 controls were studied. The proliferative activity of the endothelium and the neoangiogenetic capacity of these lesions were investigated by immunohistochemistry for the PCNA, MIB-1, Flk-1, VEGF, HIF-1α, and endoglin antibodies, respectively.

Results: Positive immunostaining of endothelial cells was observed in 86% of patients for PCNA and in 38% of the cases for MIB-1. The expression of Flk-1 was determined in the endothelium of 71% of the cases, for VEGF in 41%, for HIF-1α in 48%, and for endoglin in 64% of the individuals, respectively. The correlation of immunohistochemical and clinical data showed that VEGF was expressed significantly less in deep-seatedCCM than in superficial CCM. Neither the expression of the proliferative markers, nor the expression of the angiogenetic antibodies correlated with the age at surgery, the gender, or the episodes of recent prior hemorrhages in our patients.

Conclusions: CCM in adult patients are active lesions exhibiting endothelial proliferation and neoangiogenesis. According to our data, neoangiogenesis is more prominent in superficial CCM than in deep seated CCM, and is rarely associated with recent prior hemorrhages.