gms | German Medical Science

57th Annual Meeting of the German Society of Neurosurgery
Joint Meeting with the Japanese Neurosurgical Society

German Society of Neurosurgery (DGNC)

11 - 14 May, Essen

The International Neuroendoscopic Biopsy Study (INEBS)

Die internationale neuroendoskopische Biopsie-Studie (INEBS)

Meeting Abstract

  • corresponding author T. Riegel - Klinik für Neurochirurgie Universitätsklinikum Gießen und Marburg, Standort Marburg
  • S. Constantini - Dana Children’s Hospital Tel Aviv, Israel
  • S. Sgouros - Alder Hay Children’s Hospital Birmingham, UK
  • R. Abbott - New York University Medical Center, US
  • D. Hellwig - Klinik für Neurochirurgie Universitätsklinikum Gießen und Marburg, Standort Marburg

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocFR.12.05

The electronic version of this article is the complete one and can be found online at:

Published: May 8, 2006

© 2006 Riegel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Although neuroendoscopic biopsies (NEB) are routinely performed, the safety and validity of NEB has been studied only for a small number of patients in single centre reports. The aim of this study is to collect data on large numbers of NEB patients retrospectively at several international centres known to perform neuroendoscopic procedures on a regular basis.

Methods: Retrospective data collection from 13 centres routinely performing NEB over a period of 5 years. The essential patient data focused on all biopsy attempts. Feedback from the neuropathologist on the study form was essential.

Results: We received 292 patient data forms from13 medical centres in 9 counties. Patients’ age ranged from 0.1 to 78.7 years (median 20.4). Tumour location was pineal (34%), thalamic (18%), intraventricular (21%), tectal (12%), hypothalamic (55) and other locations (10%). Tumour size was <10mm (13%), 10-20mm (36%), and 20mm (50%). In addition to the NEB, 59 had endoscopic third ventriculostomy (ETV) and 14% septum pellucidotomy. There was one intraoperative death reported, due to massive haemorrhage. 80% had a mild bleeding during the procedure, 14% moderate, and 6% severe. Infection occurred in 3%, and other complications, mostly reversible, in 11%. Tumour types ranged across the spectrum, including astrocytoma (low-grade-32%, high-grade-13%), germinoma (11%), PNET (11%), non-neoplastic (5%), and other tumour types (18%). 105 had non-conclusive pathology

Conclusions: This is the largest series looking on the safety and validity of NEB. NEB had a relatively low, and mostly reversible, complication rate of fewer than 13%. Neuroendoscopic biopsy provided meaningful pathological data for 90% of the patients.