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56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

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Efficacy of antibiotic-impregnated ventricular catheter in reducing the CSF infection rate after placement of an external ventricular drainage

Meeting Abstract

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  • G. Toshkezi - Department of Neurosurgery, Hôpital Beaujon, Clichy, France
  • corresponding author T. Faillot - Department of Neurosurgery, Hôpital Beaujon, Clichy, France
  • M. Kalamarides - Department of Neurosurgery, Hôpital Beaujon, Clichy, France
  • J. L. Berthelot - Department of Neurosurgery, Hôpital Beaujon, Clichy, France
  • A. Redondo - Department of Neurosurgery, Hôpital Beaujon, Clichy, France

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. DocP146

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2005/05dgnc0414.shtml

Published: May 4, 2005

© 2005 Toshkezi et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

The purpose of this study was to assess the efficacy of antibiotic impregnated ventricular catheter (AIVC) in reducing cerebrospinal fluid (CSF) infection rate after placement of an external ventricular drainage (EVD).

Methods

This prospective, randomized study, was conducted over a one-year period (12/1/2003-12/1/2004) and included 46 patients aged 18 or over who underwent placement of an EVD. Each patient was randomly given either ventricular catheter impregnated with antibiotics (clindamycin and rifampicin) (AIVC group) or standard, non impregnated, ventricular catheter (control group). All catheters were inserted in the operating room and were left in place for more than 24 hours. CSF samples were taken for microbiological examination during the procedure and daily until the withdrawal of EVD. bacteriological examination of the ventricular catheter was also performed. Patients with CSF infection prior to procedure were excluded. Infection was defined by the positivity of microbiological examination of either CSF samples or catheter.

Results

48 patients underwent EVD placement during the study period. Two of them were excluded because of evidence of CSF infection prior to procedure. 13 patients received AIVC and 33 received standard catheter. Overall CSF infection rate was 8,7% in our series. The infection rate was 15,4% in the AIVC group and 6% in the control group (NS) There was a trend towards later onset of infection in the AIVC group (10 days vs 4 in the control group).

Conclusions

Our study failed to show any significant reduction of CSF infection rate after EVD placement using antivbiotic -impregnated ventricular catheter. Interpretation of these results should be cautious due to the small number of patients included in our series.