gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

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Synergistic effect of chronic bilateral subthalamic nucleus stimulation and medication in advanced Parkinson’s Disease: computerized gait analysis at 3 months and 1 year postoperatively

Synergistischer Effekt der bilateralen Tiefenhirnstimulation im Nukleus Subthalamicus und der Medikation bei fortgeschrittener Parkinsonerkrankung: Ergebnisse der computerisierten Ganganalyse nach 3 Monaten und einem Jahr postoperativ

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  • corresponding author R. Weigel - Neurochirurgische Klinik, Universitätsklinikum Mannheim, Mannheim
  • H. Bäzner - Klinik für Neurologie, Universitätsklinikum Mannheim, Mannheim
  • C. Blahak - Klinik für Neurologie, Universitätsklinikum Mannheim, Mannheim
  • H. H. Capelle - Neurochirurgische Klinik, Universitätsklinikum Mannheim, Mannheim
  • J. C. Wöhrle - Klinik für Neurologie, Universitätsklinikum Mannheim, Mannheim
  • J. K. Krauss - Neurochirurgische Klinik, Universitätsklinikum Mannheim, Mannheim

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. DocP024

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2005/05dgnc0292.shtml

Published: May 4, 2005

© 2005 Weigel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective

Computerized gait analysis was used to study prospectively the long term-term effects of both chronic bilateral subthalamic nucleus (STN) stimulation and medication with levodopa on gait in patients with advanced idiopathic Parkinson’s disease.

Methods

Eight patients with advanced Parkinson’s disease (3 women, 5 men, mean age 68.5 ys) underwent bilateral STN-stimulation. Instrumental gait analysis was performed using a computer-assisted gait analyzing system (Ultraflex, Infotronic, The Netherlands). The preoperative and postoperative (3 and 12 months after surgery) spatial and temporal gait parameters were analyzed in off-drug and on-drug conditions.

Results

In the medication-off condition, objective gait scores were improved with bilateral STN-stimulation both at the 3-month and the 12-month follow-up. Preoperative gait measurements during best medication-on states were also improved with bilateral STN-stimulation as demonstrated in the follow-up assessments. Net medication effects at 3 and 12 months after operation were equivalent to net stimulation effects.

Conclusions

Bilateral STN-stimulation resulted in a substantial improvement of gait parameteres in our cohort of elderly patients with advanced Parkinson’s disease. Net medication effects were equivalent to net stimulation effects, but the combination of both led to further improvement.