Article
Deep brain stimulation as treatment of essential tremor
Tiefenhirnstimulation in der Behandlung des essentiellen Tremor
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Authors
Published: | May 4, 2005 |
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Outline
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Objective
Deep brain stimulation (DBS) is well established as treatment in movement disorders, especially in Parkinson's disease. In our department 208 patients have been treated with DBS during the last 6 years for different indications. With the following data we report on our experience with DBS of the Nucleus ventralis intermedius (VIM) for patients with essential tremor (ET).
Methods
Between 2000 and 2004 16 patients with ET (8 male, 8 female) underwent implantation of DBS electrodes into the VIM. Before implantation of the permanent electrode intraoperative microelectrode recording and macrostimulation was performed in all cases.
Results
Implantation was bilateral in all 16 patients. According to results of intraoperative microelectrode recordings and macrostimulation 17 permanent electrodes were implanted in the central trajectory, followed by 9 in the medial and 9 in anterior trajectory, whereas only 4 were placed in the lateral or posterior trajectory. In 11 patients implantation was not symmetric. Patients were followed up with Fahn and Bain Tremor score. The averaged preoperative score was 58 (Fahn) and 57 (Bain), declined to 31 and 33 at 3-months, at 12-months control 30 and 38 were measured. Best stimulation effect was seen on the lowest contact both sides, for 5 electrodes the stimulated contact was transferred into contact 1 or 2 because of ataxia or dysaesthesia under stimulation (9 patients).
Conclusions
In ET bilateral VIM stimulation significantly reduces handicap caused by both extremity and head and neck tremor. As most effective stimulation site the centro- and medio-caudal portion of VIM was localised. After 1 year of stimulation the effect was not fading as far as our follow-up could show.