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55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

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Histopathological examination of the effects of ultrasound aspiration on brain tissue

Histopathologische Untersuchungen der Effekte des Ultraschallaspirators an Hirngewebe

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  • corresponding author Ulrich Knopp - Department of Neurosurgery, University of Luebeck, Luebeck
  • B. Habermalz - Department of Neurosurgery, University of Luebeck, Luebeck
  • A. Sepehrnia - Department of Neurosurgery, Clemenshospital Muenster, Muenster
  • H. Arnold - Department of Neurosurgery, University of Luebeck, Luebeck

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 09.92

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2004/04dgnc0375.shtml

Published: April 23, 2004

© 2004 Knopp et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Ultrasonic aspiration has been widely adopted in the resection of lesions of the central nervous system. The CUSA Ultrasonic Surgical System fragments and aspirates a wide spectrum of firm tumors of the central nervous system with little movement transmitted to adjacent normal neural structures. The CUSA system is clearly of limited value in removing extremely calcified or dense fibrous tumors. It lacks primary hemostatic properties, and conventional hemostatic techniques are necessary. Histopathological examination was performed to determine the long-term effects and the kind and extent of tissue damage.

Methods

Two lesions of different ultrasound amplitude were made in each of 20 rabbits. Histopathological examination was performed in 10 animals immediately after surgery and in ten rabbits after eight weeks of observation.

Results

The typical tissue damage surrounding the lesion is predominantly edema and neuronal death. Interestingly, no obliteration of vessels, independent of their size was observed. Even capillaries were not occluded. The typical formation after 8 weeks of observation was fibrosis and gliosis. No ultrasound-specific alterations were observed.

Conclusions

Local hyperthermia seems to be the predominant kind of lesion in ultrasonic aspiration. The mean distance of tissue damage from the place of application is about 2 mm. Eight weeks after lesioning, no specific formation of residual defects could be observed.