gms | German Medical Science

132. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

28.04. - 01.05.2015, München

Lymph node ratio has a significant influence on survival in neuroendocrine neoplasia of the ileum

Meeting Abstract

  • Anna E. Heverhagen - Universitätsklinikum Marburg, Klinik für Viszeral-, Thorax- und Gefäßchirurgie, Marburg, Deutschland
  • Martha Schuchmann - Universitätsklinikum Marburg, Klinik für Viszeral-, Thorax- und Gefäßchirurgie, Marburg, Deutschland
  • Dominik Wiese - Universitätsklinikum Marburg, Klinik für Viszeral-, Thorax- und Gefäßchirurgie, Marburg, Deutschland
  • Jens Waldmann - Universitätskliniken Giessen und Marburg, Standort Marburg, Viszeral-, Thorax und Gefässchirurgie, Marburg, Deutschland
  • Detef K. Bartsch - Universitätsklinikum Marburg, Klinik für Viszeral-, Thorax- und Gefäßchirurgie, Marburg, Deutschland
  • Volker Fendrich - Universitätsklinikum Marburg, Klinik für Viszeral-, Thorax- und Gefäßchirurgie, Marburg, Deutschland

Deutsche Gesellschaft für Chirurgie. 132. Kongress der Deutschen Gesellschaft für Chirurgie. München, 28.04.-01.05.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. Doc15dgch637

doi: 10.3205/15dgch637, urn:nbn:de:0183-15dgch6375

Published: April 24, 2015

© 2015 Heverhagen et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Introduction: Aim of this study was to evaluate the role of the lymph node metastases ratio in patients who underwent surgery due to a neuroendocrine neoplasia of the ileum.

Material and methods: 120 prospectively collected patients who underwent surgery for ileal NEN between 1999 and 2014 at our institution were retrospectively evaluated regarding their survival and their lymph node ratio at the time of primary surgery.

Results: In 106 (88,3 %) patients lymph nodes were resected as a part of the main oncological resection of the primary. After a median follow up of 48 months (range 1-157) 63 (59,4 %) patients are still alive, whereas 43 (40,6 %) patients died. Patients still alive had a mean lymph node ratio of 0.158, whereas patients who died had a lymph node ratio of 0.488 (p=0.000). The estimated median survival for patients with a lymph node ratio >50% was 70 months (range 19-121) and 113 months (range 57-169) for patients with a lymph node ratio <50%. The actual 5-year survival of patients with a lymph node ratio <50% was 72% and 28% for patients with a lymph node ratio >50%.

Conclusion: Survival is statistically significantly higher in patients with a lymph node ratio <50%. Thus, a systematic lymphadenectomy in ileal NEN will allow prognostic prediction of the course of disease.