gms | German Medical Science


Figure 2: 15dPGJ2-mediated regulation of miRNA precursor

THP-1 cells were differentiated into macrophages and incubated with different compounds as indicated for 24 h. Expression of the miRNA precursor is dose-dependently up-regulated by 15dPGJ2 (A). Neither p38/MAPK inhibitor SB203580 (B) nor PPARγ agonist rosiglitazone (C) influenced miRNA precursor expression. Phosphatase inhibitor calyculin A induced dose-dependently expression of the miRNA precursor (D). The data represent mean ± standard errors of three independent experiments. *p<0.05, **p<0.01, ***p<0.001 vs. control.