gms | German Medical Science

Bad Honnef-Symposium 2014

Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG e. V.) in Zusammenarbeit mit der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM e. V.) und dem Robert Koch-Institut (RKI)

14. - 15.04.2014, Königswinter

Monitoring of antibiotic resistance in Thuringia 2007–2012 – Evaluation of data from seven laboratories

Meeting Abstract

  • Anke Popp - Thüringer Landesamt für Verbraucherschutz, Bad Langensalza, Deutschland
  • Dagmar Rimek - Thüringer Landesamt für Verbraucherschutz, Bad Langensalza, Deutschland
  • Margarete Borg-von Zepelin - Hufeland Klinikum Mühlhausen, Deutschland
  • Reinhard Kappe - Südharz Klinikum Nordhausen, Deutschland
  • Michael Scheven - Laborpraxis Reinhöfer Greiz, Deutschland
  • Evelyn Wietschel - Laborpraxis Erfurt, Deutschland
  • Helfrid Späte - Laborpraxis Erfurt, Deutschland
  • Carsten Windmeier - Zentralklinik Bad Berka, Deutschland

Bad Honnef-Symposium 2014. Königswinter, 14.-15.04.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14bhs21

doi: 10.3205/14bhs21, urn:nbn:de:0183-14bhs216

Published: April 11, 2014

© 2014 Popp et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Background: Current regional antibiotic susceptibility data from hospitalized patients and outpatients are needed to support local networks for the defence against the spreading of multiresistant bacteria. This study monitors the development of antibiotic resistance rates in Thuringia from 2007 to 2012.

Material and methods: Results of routine susceptibility data for twelve antibiotic agents of a total of about 160,000 isolates of Staphylococcus aureus (n=40,971), Escherichia coli (n=69,459), Pseudomonas aeruginosa (n=12,932), and Enterococcus faecalis (n=38,983) from seven Thuringian microbiology laboratories were analyzed retrospectively for the years 2007 to 2012. Susceptibility testing was performed by agar diffusion test or breakpoint-testing according to the German standard DIN 58940 or EUCAST guidelines. The results were compared to nationwide German data published online by the Robert Koch Institute on the Antibiotic Resistance Surveillance website (ARS,

Results: Resistance rates of S. aureus, E. coli, and P. aeruginosa from outpatients were significantly lower than those from hospitalized patients. The rate of methicillin resistant S. aureus (MRSA) in outpatients rose from 6.9% in 2007 to 9.6% in 2012, whereas the MRSA rate remained constant at around 15.0% in small (<500 beds) and showed a slight increase from 16.3% to 17.7% in large (>500 beds) hospitals. The resistance rate of E. coli against cefotaxime as a marker for extended spectrum betalactamase (ESBL) increased from 2007 to 2012 with a stronger rise in outpatients (fivefold, from 1.3% to 6.9%) than in hospitals (from 8.3% to 14.1%). Resistance rates of P. aeruginosa against ciprofloxacin decreased from 2007 to 2012 in hospitalized patients (from 14.8 % to 10.1%). E. faecalis isolates remained highly susceptible to ampicillin.

Conclusions: In 2012 Thuringian MRSA rates remained well below nationwide levels as determined by the ARS. However, an alarming increase of ESBL rates was observed both in outpatients and hospitalized patients, with regional rates significantly higher than ARS rates in 2012.


Warweg U, Kappe R, Scheven M, Reinhöfer J, Späte H, Wietschel E, Rimek D. Vergleich der Antibiotikaresistenz im ambulanten und stationären Bereich in Thüringen für die Jahre 2007 und 2008. Chemother J. 2010;19:114-9.