gms | German Medical Science

Artificial Vision 2017

The International Symposium on Visual Prosthetics

01.12. - 02.12.2017, Aachen

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Outcome measure of clinical trial of retinal prosthesis by suprachoroidal-transretinal stimulation (STS) for patients with hand-motion vision

Meeting Abstract

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  • Takashi Fujikado - Applied Visual Science, Osaka University, Osaka, Japan
  • T. Endo - Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
  • K. Hozumi - Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
  • H. Kanda - Applied Visual Science, Osaka University, Osaka, Japan
  • T. Morimoto - Applied Visual Science, Osaka University, Osaka, Japan
  • M. Hirota - Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
  • M. Ozawa - Nidek Co., Gamagori, Japan

Artificial Vision 2017. Aachen, 01.-02.12.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. Doc17artvis25

doi: 10.3205/17artvis25, urn:nbn:de:0183-17artvis259

Published: November 30, 2017

© 2017 Fujikado et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: In pivotal clinical study of suprachoroidal-transretinal stimulation (STS) retinal prosthesis, we include patients with hand-motion (HM) vision. Because the main outcome measure is the result of light localization test, we have to define the optimum target contrast for evaluation. In this study we evaluated the deviation in reaching movement to a target with different contrast in a patient implanted with STS retinal prosthesis in the pilot study and investigated the optimal target contrast to evaluate the efficacy of retinal prosthesis for a patients with residual vision.

Methods: A STS retinal prosthesis was implanted in the right eye of 42-year-old man with advanced Stargardt disease with visual acuity of HM. In localization test, a white square target (visual angle; 10°) with different contrast (95, 85, 74%) was displayed on the PC monitor at a random position and the patient was instructed to touch the center of a target (20 trials). We measured the distance between the touched point and the center of a target and averaged (absolute deviation) in a condition with system ON and OFF during one-year follow-up.

Results: The absolute deviation with system ON was not always smaller than that with system OFF for a high contrast target (96%) but was always smaller with system ON than system OFF for a low contrast target (85%, 74%).

Discussion: Low-contrast target may be better to evaluate the accuracy of localization in patients implanted with retinal prosthesis and with residual natural vision.

Acknowledgement: This work was supported by AMED grant, Japan