Figure 1: Time course of burn surface progression given in percent of the total interspace area in untreated animals (controls: white bars), as well as in animals treated with cold water (blue bars) respectively warm water (red bars) (A). Time course of burn depth progression in untreated animals (white bars), as well as in animals treated with cold water (blue bars) respectively warm water (red bars) (B). Mean ± SEM; *p<0.05 vs. controls; #p<0.05 vs. cold water treatment; n=7/group. Local treatment of either temperature delays secondary burn depth progression without preventing final burn depth at day 7. Burn depth progression score: 1. epidermis; 2. superficial dermis; 3. intermediate dermis; 4. deep dermis; 5. muscle. n=7/group. Tissue morphology 1 h (C) and 7 days after burn in an animal without treatment (D), as well as after cold water (E) or warm water-treatment (F). Note the decreased width of interspace necrosis after cold water and particularly after warm water-treatment.