Figure 3: Time course of interspace perfusion in cold water-treated animals (controls; blue bars), as well as in animals first treated with EPO at a dosage of 500 IU/kg bw after 45 minutes (light grey, EPO500 45 min) or after 6 hours (intermediate grey, EPO500 6hrs) or at a dosage of 2500 IU/kg bw after 45 minutes (dark grey, EPO2,500 45 min) (A). Mean ± SEM; *p<0.05 vs. controls; &p<0.05 vs. EPO500 6 hrs and EPO2,500 45 min; n=7/group. Tissue morphology 7 days after burn in a control animal (B) as well as in animals treated with EPO500 45 min (C), EPO500 6 hrs (D) or EPO2,500 45 min (E). Note the decreased width of interspace and overall necrosis after EPO treatment, especially after administration of EPO500 45 min.