Figure 5: Inducible nitric oxide synthase (iNOS)-positive cells in cold water-treated animals (controls; blue bars), as well as in animals treated with EPO500 45 min (light grey), EPO500 6 hrs (intermediate grey) or EPO2,500 45 min (dark grey) (A). Mean ± SEM; *p < 0.05 vs. controls; &p < 0.05 vs. EPO500 6 hrs; n=7/group. Staining for iNOS at day 1 in a controls animal (B), as well as in an animal receiving EPO500 45 min (C), EPO500 6 hrs (D) and EPO2,500 45 min (E), respectively. Positive cells are represented by red staining, which is only seen in EPO-treated animals (arrow heads). Scale bar 15 µm.