gms | German Medical Science


Figure 4: Proteins associated with adaptation. Myosin 1c is detectable in the hair bundle and reaches its highest concentration at the two ends of the tip links. Myosin VIIa is found in the whole hair bundle. Both proteins are also detectable in the region of the pericuticular zone (pz). Abbbreviations: IQ (regulatory light-chain-binding domain), HDACI (histone deacetylase interacting domain), EFH (EF hand domain), cc (coiled-coil domain), MyTH4 (myosin tail homology domain 4), FERM (4.1/ezrin/radixin/moesin-like domain), SH3 (Src homology 3 domain), PDZ (PSD-95/ Dlg/ ZO-1-like domain) (Figure modified after Vollrath et al. [9]).