gms | German Medical Science

GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKHC)

ISSN 1865-1038

Severe sinonasal epithelial dysplasia to malignancy

Poster Onkologie

  • corresponding author Eugen Radu Boia - Spitalul Clinic Municipal Timisoara, Timisoara, Romania
  • Marioara Poenaru - University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania
  • Caius Doros - University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania
  • Nicolae Constantin Balica - University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania
  • Simina Boia - University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania

GMS Curr Posters Otorhinolaryngol Head Neck Surg 2016;12:Doc183

doi: 10.3205/cpo001534, urn:nbn:de:0183-cpo0015340

Published: April 11, 2016

© 2016 Boia et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Abstract

Right sinonasal non-keratinizing squamous cell carcinoma and hard palate, middle infraorbital area, middle cranial fossa space involvement were present in an 18-year-old male patient. The patient was admitted presenting: recurrent sinusitis, right sinonasal tumor and bilateral cervical lymph node involvement. The patient presented laterocervical bilateral metastatatic masses.

Biopsy was performed and sent to the Pathology Service. Usual histological techniques were performed on the specimen. The polypoid lesion showing a connective tissue core with seromucous acini and moderate quantity of inflammatory cells (neutrophils, eosinophils, lymphocytes, histiocytes) was visible on hematoxylin eosin slides. The epithelium was pseudostratified, being composed of ciliated columnar cells and presenting areas of squamous metaplasia. A malignant tumor formed by epithelioid cells was visualised in these zones, with eosinophilic cytoplasm and vesicular nucleus containing prominent nucleolus. The cells were disposed in sheets, surrounded by fibrous connective stroma. Severe dysplasia was visible at the transition site between normal epithelium and malignant tumor, as precursor lesion. The complementary immunohistochemical tests were consistent with a non-keratinizing squamous carcinoma arising in a fibro-glandular polyp with concomitant severe epithelial dysplasia, as a starting lesion.

After extensive radiochemotherapy the patient was sign and symptom free, at 12 months no recurrence was noted.

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