gms | German Medical Science

GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKHC)

ISSN 1865-1038

Hemagiomas and vascular malformation on face and neck - with intralesional bleomycin injection


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  • corresponding author Daniela Tatulescu - Medical Center for Diagnostik and Treatment of Defens Ministry, Academician Stef, Bukarest, Rumänien
  • Inout Secheli - Pediatric Surgery Clinic, Univ.Childrens Hospital, Bukarest, Rumänien
  • Marian Secheli - Pediatric Surgery Clinic, Univ.Childrens Hospital, Bukarest, Rumänien

GMS Curr Posters Otorhinolaryngol Head Neck Surg 2006;2:Doc020

The electronic version of this article is the complete one and can be found online at:

Published: April 24, 2006

© 2006 Tatulescu et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Bleomycin, an antineoplasic polipeptidic antibiotic, has been recently used in treatment of vascular anomalies, as a sclerosing agent if it is injected intralesional. We report a study of 4 patients with ages between 3 weeks and 12 years, admitted in “Maria Sklodowska Curie” Children Hospital Bucharest in Surgery Department, and treated with Bleomycin intralesional injections, for vascular anomalies inoperable because of the large surfaces involved or volume of the lesions and special locations on face and neck.

For an accurate pursuance and estimation of the efficacy of the treatment, we use the classification of vascular anomalies suggested by Mulliken and Glowacki in 1982 which allowed us a quick diagnosis, otherwise unconfirmade by the microscopical exam in most of the cases, as vascular lesions treated this way were never operated before. Excellent results allowed the usage of Bleomicycin on a large scale in the locale treatment of vascular anomalies located especialy on the child´s face and neck.

The results are encouraging considering the fact that it is a simple procedure, easy to perform (even we use general anesthesia), very cheap for our country, and with insignificant adverse reations and we recomand this treatment in difficult cases with special locations that cannot be surgical treated.