gms | German Medical Science

54. Jahrestagung der Norddeutschen Orthopädenvereinigung e. V.

Norddeutsche Orthopädenvereinigung

16.06. bis 18.06.2005, Hamburg

Treatment of cartilage defects of the knee with a three-dimensional collagen matrix and autologous chondrocytes

Meeting Abstract

  • corresponding author J. Steinhagen - Klinik und Poliklinik für Orthopädie, Universitätsklinikum Hamburg-Eppendorf, Hamburg
  • J. Bruns - Hamburg
  • J. Petersen - Hamburg
  • W. Rüther - Hamburg

Norddeutsche Orthopädenvereinigung. 54. Jahrestagung der Norddeutschen Orthopädenvereinigung e.V.. Hamburg, 16.-18.06.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05novK5.07

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/nov2005/05nov018.shtml

Veröffentlicht: 13. Juni 2005

© 2005 Steinhagen et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Introduction

The limited repair of articular cartilage is still a well-known problem. Although the clinical results of autologous chondrocyte transplantation were satisfactory, several problems are still remaining. The aim of this study was to evaluate early clinical results of a three-dimensional collagen matrix (CaReS®) seeded with autologous chondrocytes in the treatment of deep cartilage defects.

Material and methods

25 patients (mean age 33.71) with chondral or osteochondral lesions of the medial or lateral femoral condyle (ICRS stage 3 or 4) were evaluated clinically (ICRS-score / IKDC-score) and radiologically (x-ray, MRI) before and after surgical treatment with a collagen I matrix seeded with autologous chondrocytes. The minimum follow-up period was 1 year.

Results

During follow-up period the IKDC score increased from 38.96 pts. (preoperative) to 65.34 pts. 12 month after surgical treatment. The change versus baseline was 22.68 pts. (p-value <0.0001). Patients with a single lesion exhibited significant better results than patients with two or more lesions. In contrast there were no differences in the clinical outcome after surgical treatment between cartilage lesions grade 3 or 4. The value of IKDC-score was dependent on the defect size post debridement (mean change versus baseline after 12 month: defect size 4-6cm2 44.83 pts.). MRI showed a continuous integration of the transplants into the surrounding cartilage.

Conclusion

Early-term results of collagen I matrix transplantation seeded with autologous chondrocytes showed a distinct improvement in clinical and radiological parameters. Regarding to ACT, matrix based techniques could be a continuative step in cartilage reconstruction.