gms | German Medical Science

33. Internationale Konferenz für Elektrokardiographie

Internationale Konferenz für Elektrokardiographie

The Circadian Index as new simple method for assessment of the circadian heart rate

Meeting Abstract

  • corresponding author presenting/speaker L. Makarov - Moscow Institute Pediatry and Children Surgery, Moscow, Russland
  • S. Chuprova - Moscow Institute Pediatry and Children Surgery, Moscow, Russland
  • V. Komoliatova - Moscow Institute Pediatry and Children Surgery, Moscow, Russland
  • E. Petukhova - National Medical Surgery Center after N.I.Pirogov, Moscow, Russland

33rd International Congress on Electrocardiology. Cologne, 28.06.-01.07.2006. Düsseldorf, Köln: German Medical Science; 2007. Doc06ice110

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Veröffentlicht: 8. Februar 2007

© 2007 Makarov et al.
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Aim of this study was to assess of circadian profile of heart rate in pts with cardiac diseases.

Methods: 24 hr Holter monitoring (HM), Oxford, UK, was performed in 201 pts 3-45 years. Indications for HM recording were arrhythmias detected on 12 leads ECG and diseases with high risk of life-threatening arrhythmias: extrasystoles (EX) 87 pts; atrial flutter (AF) 7 pts; sick sinus syndrome (SSS) 24 pts; complete AV block (AVB) 35 pts; long QT syndrome (LQTS) 11pts, catecholaminergic ventricular tachycardia (CVT) 10 pts; primary pulmonary hypertension (PPH) 15 pts, ishemic heart deseases (IHD) 12 pts. The control group (C) consisted of 115 healthy persons 3- 45 years. Circadian Index (CI) was calculated as ratio of mean HR (bpm) during awake period to mean HR (bpm) during night-sleep time.

Results: CI in patients with arrhythmias is summarized in Table 1 [Tab. 1]. * P <0,05 with control group Also the CI was calculated by the literature data (from the data of 20 published works) in various groups on healthy subjects and pts aged 2-79 years. In healthy subjects CI was stable irrespective of sex and age - 1,33 ± 0, 05. The reduction of CI < 1,2 was in cardiovascular pts with deterioration of the prognosis and autonomic denervation (diabetes mellitus with autonomic neuropathy). In neurological pts free of autonomic heuropathy CI was normal. CI > 1,46 was seen in patients with a basic high sensitivity to catecholamines.

Conclusion: CI reflected a ‘strong’ component in architecture of circadian heart rate. Decreased of CI shows the reduced of autonomic influence on heart rate. Increased of CI reflected high heart rates sensibility to sympathetic influence.