Artikel
Correlation Of Abnormalities Of Vegetative Regulation Of Heart Rhythm With The Level Of Autoantibodies To Nerve Growth Factor In Children With Long Qt Syndrome
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Autoren
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A. Abakumov
- Federal Medical Biological Agency, Moscow, Russland
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S. Chuprova
- Russian Center for Children's Arrhythmias, Moscow, Russland
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T. Klushnik
- Mental Health Research Center, Moscow, Russland
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G. Galkin
- Federal Medical Biological Agency, Moscow, Russland
| Veröffentlicht: | 8. Februar 2007 |
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Gliederung
Text
Nerve growth factor (NGF) is protein, which is necessary for normal functioning of sympathetic nervous system. The purpose of this study was to determine the level of autoantibodies to nerve growth factor (aAB) and to estimate heart rate variability (HRV) in patients (pts) with long QT syndrome (LQTS) and to compare the received results to the appropriate results in pts with vasovagal syncope (v.s.).
Materials and methods: 55 pts were examined at the age from 8 to 16: 30 with LQTS (21 with syncope), 25 with v.s. Estimation of vegetative regulation of heart rhythm (HR) was conducted by maths analyses of parameters of HRV. Control group made 64 healthy children of correspondent age and sex. The level of aAB was considered increased at values exceeding 0,86, high at values exceeding 1 u.o.d.
Results: In the group of pts with LQTS and pts with v.s. the average level of aAB didn’t vary significantly (0,92±0,27 and 0,86±0,14 u.o.d. accordingly). The percentage (%) of pts with high level of aAB was higher in the group of pts with LQTS (23,3% and 12% accordingly). In spite of the fact that the average level of aAB in syncopal and non-syncopal pts with LQTS didn’t vary significantly in-between, the % of pts with high level of aAB among pts without syncope was considerably higher than among those with syncope (55,6% and 9,5% accordingly). While analyzing the indices of HRV in pts with LQTS in sub-group of pts with high level of aAB (did not receive beta-blockers) a significant (comparatively with norm) increase of indices of Mean, SDNN, гMSSD and pNN50 (increased HRV) was noticed in 71,4% of pts, considerable decrease of SDNN, гMSSD and pNN50 at the background of normal index of Mean – in 14,3% of pts. In sub-group of pts with increased and normal level of aAB (76,7%) increased HRV was noticed in 34,8% of pts. Decrease of HRV was noticed in 4,3% pts with heavy clinical course. While analyzing HRV in pts with v.s. in sub-group of pts with high level of aAB in all cases normal HRV was noticed.
Conclusions: The largest % of pts with high level of aAB was discovered among pts without syncope with LQTS. Detection of the largest % of pts with increased HRV among pts with LQTS and high level of aAB allows to suggest in them a certain correlation of level increase of aAB with vegetative regulation of HR.
