gms | German Medical Science

33. Internationale Konferenz für Elektrokardiographie

Internationale Konferenz für Elektrokardiographie

On The Origin Of Palpitations In Patients With Mitral Valve Prolapse Syndrome. Role Of Long Term Adrenergic Beta Blockade

Meeting Abstract

  • corresponding author presenting/speaker E. Pereira da Silva - University Hospital of Santa Maria, Lisboa, Portugal
  • M. Mendes Petro - University Hospital of Santa Maria, Lisboa, Portugal
  • L. Neves - University Hospital of Santa Maria, Lisboa, Portugal
  • M. Pires Bicho - Faculty of Medicine, Lisboa, Portugal
  • M.G. Lopes - University Hospital of Santa Maria, Lisboa, Portugal

33rd International Congress on Electrocardiology. Cologne, 28.06.-01.07.2006. Düsseldorf, Köln: German Medical Science; 2007. Doc06ice042

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/ice2006/06ice042.shtml

Veröffentlicht: 8. Februar 2007

© 2007 Pereira da Silva et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Question: 1.Occurrence of palpitations and rhythm disturbances in mitral valve prolapse syndrome MVPS patients (P) with high levels of catecholamines. 2.Effect of long term beta blockade on these findings.

Material and Methods: 20 normal individuals(N)–8 male(M) (49.9+-12.9y) and 12 female(F) (41.8+-11.8y). 46 P with MVPS-15 M (49.3+-15.5y) and 31 F (42.0+-12.8y). Phase1–In both N and P free of medication, determination of 24 hours urinary epinephrine (E) and norepinephrine (NE) by HPLC, and 24h Holter monitoring. Phase2–MVPS P underwent the same tests while taking Propranolol by 10-12 months.

Results: In ng/mg of creatinine, E levels in M were 5.1+-2.5(N), 9.1+-3.9(Ph1), 7.9+-3.1(Ph2). In F, 6.2+-3.5(N), 13.0+-9.7(Ph1), 10.7+-6.7(Ph2). NE levels in M were 22.2+-7.2(N), 36.8+-16.8(Ph1), 27.4+-10.6(Ph2). In F, 28.1+-7.3(N), 46.2+-18.1(Ph1), 33.0+-12.9(Ph2). Extrasystoles in 35% of the N and in 100% of MVPS. Palpitations in 25% of the N and 59% of MVPS. Episodes of palpitations in 24 hours 4.7+-5.3(M), 5.0+-4.7(F). No correlation between palpitations and extrasystoles. Correlations between: palpitations and sinus tachycardia (p=0.02),number of episodes of palpitations and E levels, extrasystoles and E levels. In phase 2, heart rate was lower than in phase1. Extrasystoles in 22% of the P. Palpitations in 52% of all P with 1.5+-1.6(M) and 1.6+-1.9(F) episodes in 24 hours. Correlations between: palpitations and sinus tachycardia (p<0.02), number of episodes of palpitations and E levels. No correlation between palpitations and extrasystoles.

Conclusions: MVPS patients had more palpitations and more extrasystoles, both correlated with the higher levels of Epinephrine. Palpitations did not correlate with extrasystoles but with sinus tachycardia. With long term beta adrenergic blockade, palpitations improved and their correlation with sinus tachycardia persisted.