gms | German Medical Science

33. Internationale Konferenz für Elektrokardiographie

Internationale Konferenz für Elektrokardiographie

Drug Induced Changes Of The QT Interval In Guinea Pigs Measured By Contactless Noninvasive Magnetocardiography

Meeting Abstract

  • corresponding author presenting/speaker U. Steinhoff - Physikalisch-Technische Bundesanstalt, Berlin, Germany
  • S. Knappe-Grueneberg - Physikalisch-Technische Bundesanstalt, Berlin, Germany
  • F. Wiekhorst - Physikalisch-Technische Bundesanstalt, Berlin, Germany

33rd International Congress on Electrocardiology. Cologne, 28.06.-01.07.2006. Düsseldorf, Köln: German Medical Science; 2007. Doc06ice011

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Veröffentlicht: 8. Februar 2007

© 2007 Steinhoff et al.
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Question: The reliable assessment of drug induced changes of the QT interval in animals is an important task in safety pharmacology. Contactless noninvasive magnetocardiography (MCG) might provide an alternative method to the use of telemetric ECG devices. MCG and ECG were performed simultaneously to clarify the relation between QT intervals as assessed by ECG or MCG.

Method used: Multichannel MCG was measured in 11 conscious guinea pigs and simultaneous ECG and MCG was performed in the same animals under anesthesia. Isoproterenol and d,l-sotalol were applied as test substances in the anesthetized animals, since those drugs are known to induce different alterations of the normal repolarization mechanisms. The measurement protocol has been approved by the local ethics committee.

Results: The data quality of contactless MCG allowed a reliable analysis of QT intervals. The increase of heart rate after isoproterenol and the decrease after sotalol application could be followed on a beat by beat basis up to 20 minutes. QTc prolongation after sotalol and QTc shortening after isoproterenol were reflected in MCG and ECG. A statistical comparison of PQ, QRS, QT and QTc intervals in anesthetized animals demonstrated the equivalence of ECG and MCG. The use of a multichannel MCG system enabled the evaluation of spatial features of the depolarization and repolarization process.

Conclusion: Noninvasive contactless multichannel MCG is equivalent to ECG in the assessment of drug induced QT interval changes in guinea pigs.

Table 1 [Tab. 1].