Artikel
Preterax in German patients with a new diagnosis of hypertension: results of the PRIMUS study
Preterax zur Behandlung deutscher Patienten mit Erstdiagnose einer Hypertonie: Ergebnisse der PRIMUS Studie
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Autoren
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P. Trenkwalder
- Klinikum Starnberg (Starnberg, D)
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H. Holzgreve
- Internist - Kardiologischer Praxis (München, D)
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T. Risler
- Universität Tübingen (Tübingen, D)
| Veröffentlicht: | 8. August 2006 |
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Gliederung
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Rationale: Recent guidelines (ESH/ESC, German Hypertension League) recommend low-dose combinations (LDC) for initial treatment of hypertension (HT). Preterax®, consisting of ACE-inhibitor perindopril 2 mg and diuretic indapamide 0.625 mg, is the only LDC approved for first-line antihypertensive therapy in several European countries including Germany.
Objective: To evaluate in general practice the efficacy and tolerability of Preterax® in German patients with a new diagnosis of HT.
Design: For this prospective, open-labelled, multicenter trial, 1892 GPs in Germany recruited 8023 patients with HT (SBP>140 and/or DBP>90), including 3015 with a new diagnosis of HT. Treatment consisted of Preterax®o.i.d. for 12 weeks, doubling of the dose was possible. SBP, DBP, normalization rate (SBP/DBP <140/90 mm Hg), responder rate (SBP/DBP <140/90 and/or SBP reduction >15 and/or DBP reduction >10 mm Hg), efficacy and tolerability according to GP`s judgement (from "excellent" to "insufficient") were evaluated. A descriptive statistical analysis was performed.
Results: Mean age in the 3015 patients with a new diagnosis of HT was 55.2 (+11.5) years. Baseline SBP was 166.1 (+13.8), DBP 97.2 (+8.6) mm Hg. 83.2% of patients had Stage 2 or 3 HT, and 84% had additional risk factors (according to current HT guidelines). In 8.3% of patients dose of Preterax® was doubled during treatment. Preterax® decreased SBP by 30.5 (+13.8) and DBP by 15.3 mm Hg (+9.2). Responder rate was 98%, and normalization rate for all patients 54,2% and 77,6% in patients with Stage 1 HT. Both efficacy and tolerability of Preterax® were evaluated as "excellent/good" in 90% of patients. No unexpected adverse effects were observed.
Conclusion: The LDC Preterax® showed excellent antihypertensive efficacy and tolerability in a large population of German patients with a new diagnosis of HT. These results in daily practice confirm that Preterax® is a suitable first-line treatment of HT, as recommended in recent guidelines.
