Artikel
Rat chromosome 19 of the SHR strain contains genetic factors that protect against salt-sensitive hypertension and cardiovascular hypertrophy in the Dahl SS rat
Das SHR Chromosom 19 enthält genetische Faktoren, die die Dahl SS Ratte gegen salz-sensitive Hypertonie und kardiovaskuläre Hypertrophie schützen
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Veröffentlicht: | 8. August 2006 |
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Recently, we have identified a quantitative trait locus linked to cardiovascular hypertrophy in a salt-fed F2-population derived from salt-sensitive Dahl (SS) and spontaneously hypertensive (SHR) rats. This study sought to test the relevance of rat chromosome 19 (RNO19) for target organ damage in SS. We therefore generated a speed consomic stain in which RNO 19 from SHR was introgressed into the SS genetic background, thus creating the SS-19SHR strain.
Male animals (n=14-21) were studied either under a normal (0.2% NaCl) or a high salt diet (4% NaCl) beginning at 6 weeks of age for 8 weeks, respectively. All measurements were performed at the age of 14 weeks. Systolic blood pressure (SBP) measurements were performed on three consecutive days by tail-cuff method.
SBP in the salt-fed SS-19SHR was significantly lower compared to the SS rats (186 +/- 30 vs. 213 +/- 14 mmHg, p<0.0001). More importantly, the relative weight of the left ventricle in salt-fed SS-19SHR (2.50 +/- 0.28 mg/g) was similar to that of SHR (2.61 +/- 0.23 mg/g) and significantly reduced compared to SS (3.1 +/- 0.5 mg/g, p<0.00001). In addition, the relative weight of the aorta was also significantly lower in salt-fed SS-19SHR rats (1.41 +/- 0.24 mg/mm) compared to SS (1.65 +/- 0.2 mg/mm, p= 0.0046). These results show that there is at least one genetic locus on RNO19 that protects the SS rat against salt-induced progression of hypertension and cardiovascular hypertrophy