gms | German Medical Science

28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

24. bis 27.11.2004, Hannover

Adhesions molecules and homocysteine in hypertensive patients with coronary heart disease

Adhäsionsmoleküle und Homocystein bei Hypertonikern mit koronarer Herzkrankheit

Meeting Abstract (Hypertonie 2004)

Suche in Medline nach

  • S. Gruska - Klinik für Innere Medizin A (Greifswald, D)
  • I. Ehrlich - Klinik für Innere Medizin A (Greifswald, D)
  • H.-J. Rose - Insitut für Klinische Chemie (Greifswald, D)
  • G. Kraatz - Klinik für Innere Medizin A (Greifswald, D)

Hypertonie 2004. 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Hannover, 24.-27.11.2004. Düsseldorf, Köln: German Medical Science; 2005. Doc04hochP102

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2004/04hoch102.shtml

Veröffentlicht: 10. August 2005

© 2005 Gruska et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

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Objective: Hyperhomocysteinemia and homocysteine-induced endothelial dysfunction are thought to play an important role in the pathogenesis of vascular atherogenic propensity affecting vasoregulation, cell proliferation, platelet aggregation and leucocyte recruitment and adhesion. We investigated the association between soluble adhesions molecules (sVCAM-1, sICAM-1, sL-Selectin), homocysteine and the occurence of coronary heart disease (CHD) in hypertensive patients.

Patients/Methods: Only hypertensives without diabetes and with normal renal function were included. All 84 patients were diagnosed by cardiac catheterization. Measurements of soluble adhesions molecules (sVCAM-1, sICAM-1 Beckmann Coulter GmbH, sL-Selectin R&D Systems) were performed with enzyme immuno assays. Homocysteine concentration was measured by HPLC (Recipe GmbH). Furthermore, in a subgroup of 43 patients, other risk factors for CHD such as oxidized LDL (Immundiagnostik AG), lipoproteine (a) and von Willebrand factor were determined.

Results: CHD was seen in 44 (30 male, 14 female) and absent in 40 (19 male, 21 female) patients. Mean plasma concentrations of all adhesions molecules investigated were not significantly different between the groups. Homocysteine concentration was significantly higher in patients with CHD (17.4±14.1 µmol/l) than in those without CHD (14.9±6.8 µmol/l, p=0.04). In 19 patients with CHD, Lp(a) was significantly increased compared to 24 patients without CHD (339.5±346.9 vs. 183.2±164.7 mg/l, p=0.006). The same was true for the von Willebrand factor (with CHD 196.1±56.1; without CHD 160.7±52.1 %). Mean concentration of oxidized LDL did not show any significant differences between the groups (with CHD 14.9±4.6; without CHD 15.7±4.0 mU/l).

Conclusion: In non diabetic hypertensives with normal renal function an increased endothelial activity in correlation to CHD was not found, but an elevated homocysteine level seems to be a risk factor for CHD.